ArticleEcotoxicology (London, England)2021
Exogenous melatonin and salicylic acid alleviates cadmium toxicity in safflower (Carthamus tinctorius L.) seedlings.
Article in Ecotoxicology (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- Melatonin pre-treatment mitigates cadmium toxicity in maize seedlings by regulating hydrological status, physio-biochemical, and hormonal responses.BMC plant biology · 2026Article
- Reclaiming multi-contaminated soil: melatonin alleviates cadmium and microplastic toxicity to restore rice growth and yield.RSC advances · 2026Article
- Hydrogen-rich water alleviates cadmium stress in Chinese flowering cabbage by enhancing antioxidant capacity, improving photosynthesis, and reducing cadmium uptake.Frontiers in plant science · 2026Article
- Plant melatonin: roles and regulatory mechanisms in plant growth, development, and responses to biotic and abiotic stresses.Plant signaling & behavior · 2025Review
- Comparative Efficacy of Melatonin and Brassinolide in Mitigating the Adverse Effects of Cadmium onInternational journal of molecular sciences · 2025Article
- Effects of exogenous melatonin on drought stress in celery (Apium graveolens L.): unraveling the modulation of chlorophyll and glucose metabolism pathways.BMC genomics · 2024Article
- Salicylic Acid and Melatonin Synergy Enhances Boron Toxicity Tolerance via AsA-GSH Cycle and Glyoxalase System Regulation in Fragrant Rice.Metabolites · 2024Article
- Low concentrations of methyl jasmonate promote plant growth and mitigate Cd toxicity in Cosmos bipinnatus.BMC plant biology · 2024Article
- Role of methylglyoxal and glyoxalase in the regulation of plant response to heavy metal stress.Plant cell reports · 2024Review
- Transcriptome Profiling, Physiological and Biochemical Analyses Reveal Comprehensive Insights in Cadmium Stress inInternational journal of molecular sciences · 2024Article
- The potential of melatonin and its crosstalk with other hormones in the fight against stress.Frontiers in plant science · 2024Review
- Synergistic effects of gamma-aminobutyric acid and melatonin on seed germination and cadmium tolerance in tomato.Plant signaling & behavior · 2023Article
- Silicon Combined with Melatonin Reduces Cd Absorption and Translocation in Maize.Plants (Basel, Switzerland) · 2023Article
- Melatonin Involved in Protective Effects against Cadmium Stress inInternational journal of molecular sciences · 2023Article
- Comparative Physiological and Transcriptomic Analyses of Improved Heat Stress Tolerance in Celery (International journal of molecular sciences · 2022Article
- Metabolome and transcriptome association analysis revealed key factors involved in melatonin mediated cadmium-stress tolerance in cotton.Frontiers in plant science · 2022Article
- Melatonin Confers Plant Cadmium Tolerance: An Update.International journal of molecular sciences · 2021Review
- Effects of Melatonin on Morphological Characteristics, Mineral Nutrition, Nitrogen Metabolism, and Energy Status in Alfalfa Under High-Nitrate Stress.Frontiers in plant science · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The co-application of exogenous 100 µM melatonin (MT) and 100 µM salicylic acid (SA) on 21-day-old safflower seedlings grown in the presence of cadmium (Cd, 100 µM) toxicity was investigated. The application of MT, SA, or MT + SA efficiently improved toxicity symptoms and declined Cd toxicity as shown by a considerable rise in plant biomass production and chlorophyll content accompanied by decreased level of oxidative stress markers. In Cd stressed plants, the simultaneous application of MT and SA led to sharp decreases in MDA and H2O2 amounts (61.04 and 49.11%, respectively), related to plants treated with Cd alone. With respect to the control, a 41 and 48% increment in reduced glutathione (GSH) and ascorbate (ASC) content was recorded in Cd-treated seedlings. Though, with the addition of MT, SA, or MT + SA, the content of GSH and ASC increased more. The application of MT, SA, or MT + SA caused a sharp induction in phytochelatin content of the leaves of Cd-treated seedlings, while in roots, the highest PC content was recorded only in the presence of MT, which was about 1.8-fold greater than in plant treated with Cd alone. The activity of enzymes responsible for the ascorbate-glutathione cycle and glyoxalase system considerably improved by using MT, SA, or the combination of MT and SA. Our findings suggest a possible synergic interaction between MT and SA in tolerating Cd toxicity by reducing Cd uptake, improving chlorophyll biosynthesis and accelerating ascorbate-glutathione cycle as well as the modulation of glyoxalase system.
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