Evidence map›Paper›PMID 33624200›Full record

Trial reportClinical oral investigations2021

Gingival depigmentation with diode and Er,Cr:YSGG laser: evaluating re-pigmentation rate and patient perceptions.

Walid Altayeb, Omar Hamadah, Bahaa Aldin Alhaffar, Ahmed Abdullah, Georgios Romanos

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07410156 narecruitingnot on this mapstarted 2026, after this paper: background citation

Clinical Evaluation of Microneedling Technique With Topical Application of Silymarin on Gingival Hyperpigmentation in Comparison With Diode Laser and Scalpel Methods. A Randomized Clinical Trial

TypeinterventionalSponsorFayoum UniversityRan2026 to 2027Enrolled30ConditionsGingival Pigmentation, Gingival HyperpigmentaionArmsGingival Depigmentation with Conventional Method, Gingival Depigmentation with Diode Laser, Gingival Depigmentation with Microneedling and Silymarin Application
NCT07520266 nacompletednot on this mapstarted 2023, after this paper: background citation

Comparison of Diode and Er,Cr:YSGG Lasers in Gingival Depigmentation: a Split-mouth Randomized Trial

TypeinterventionalSponsorCan Tho University of Medicine and PharmacyRan2023 to 2025Enrolled38ConditionsGingival HyperpigmentationArmsEr,Cr:YSGG laser, Diode laser
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. How Effective Is Vitamin C for Gingival Depigmentation? A Scoping Review.Clinical and experimental dental research · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 4 countries.

Walid AltayebDepartment of Periodontology, Tamim Dental Polyclinic, P.O. Box 13876, Alwaab Street, Doha, Qatar. draltayeb@hotmail.com.ORCID http://orcid.org/0000-0001-9069-3557
Omar HamadahDepartment of Oral Medicine, Faculty of Dental Medicine, Damascus University, Damascus, Syria.
Bahaa Aldin AlhaffarDepartment of Oral Periodontology, Faculty of Dental Medicine, Damascus University, Damascus, Syria.
Ahmed AbdullahGraduate School, Abertay University, Dundee, UK.
Georgios RomanosDepartment of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
Damascus University · SYAbertay University · GBQatar Airways (Qatar) · QAStony Brook School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the efficiency of depigmentation, patient perceptions, and the recurrence rates of physiological gingival pigments during a 2-year follow-up after ablative depigmentation using two laser wavelengths: diode 940 nm and Er,Cr:YSGG 2780 nm. MATERIALS AND

methodsSixty patients exhibiting physiological melanin hyperpigmentation in the buccal maxillary gingiva were randomly divided into two equal groups treated with an Er,Cr:YSGG laser at 2780 nm, and a 940 nm diode laser, respectively. The depigmentation procedure essentially involves the ablation of epithelial tissue exhibiting melanin pigmentation. The intensity and extensity indices of gingival pigments were evaluated at baseline, 1 month, 1 year, and 2 years.

resultsAt all time points following depigmentation treatment, oral pigmentation index (OPI) and melanin pigmentation index (MPI) scores were less significantly (p <0.05) compared to the baseline in both groups. Treatment was significantly faster with Er,Cr:YSGG laser and required no anesthesia, with faster healing and less postoperative discomfort after 1-week of treatment, compared to the diode laser treatment (p <0.001). The re-pigmentation intensity and extensity were higher significantly in the Er,Cr:YSGG group than in the diode group at 1 year and 2 years (p <0.05).

conclusionBoth lasers efficiently removed gingival pigments with comparable clinical outcomes and overall positive patient experience. Diode laser treatment exhibited better long-term stability of gingival color, with a lower incidence of re-pigmentation. CLINICAL RELEVANCE: The color of the gingiva plays an important role in the esthetics of oral soft tissues and the overall ideal smile. Laser-assisted gingival depigmentation is an effective, comfortable, and reliable technique with good esthetical outcomes. The rate of re-pigmentation was affected by the laser wavelength and the technique used.

Indexed as

Lasers, Solid-StateLaser TherapyEsthetics, DentalGingivaHumansPerceptionPigmentationAblationEstheticGingival hyperpigmentationLaserMelanin

Identifiers

PMID33624200
OpenAlexW3132179842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.