ArticleInternational journal of legal medicine2021
Intra-bone nuclear DNA variability in Second World War metatarsal and metacarpal bones.
Article in International journal of legal medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
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- Computed tomography differentiation of compact and cancellous bone tissue in short and sesamoid bones.Radiology and oncology · 2025Article
- Review
- Testing the informativeness of Y-STR and mitochondrial DNA control region markers in an attempt to predict ancestry of World War II victims from Slovenian mass grave.International journal of legal medicine · 2025Article
- Patellae as a source of DNA in forensic and archaeological analysis.International journal of legal medicine · 2025Article
- Article
- Comparison of the optimal and suboptimal quantity of mitotype libraries using next-generation sequencing.International journal of legal medicine · 2024Article
- Measure quantity of mitochondrial DNA in aged bones or calculate it from nuclear DNA quantitative PCR results?International journal of legal medicine · 2023Article
- Comparison of DNA preservation and ATR-FTIR spectroscopy indices of cortical and trabecular bone of metacarpals and metatarsals.Scientific reports · 2023Article
- Eye and hair color prediction of an early medieval adult and subadult skeleton using massive parallel sequencing technology.International journal of legal medicine · 2023Article
- Comparison of DNA preservation between adult and non-adult ancient skeletons.International journal of legal medicine · 2022Article
- Comparison of DNA preservation between ribs and vertebrae.International journal of legal medicine · 2022Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
DNA analysis of Second World War skeletal remains is challenging because of the limited yield of DNA that is usually recovered. Recent forensic research has focused on determining which skeletal elements are superior in their preservation of DNA, and little focus has been placed on measuring intra-bone variability. Metatarsals and metacarpals outperformed all the other bones in DNA yield when analyzing all representative skeletal elements of three Second World War victims, and intra-bone variability was not studied. Soft-tissue remnants were found to contribute to higher DNA yield in trabecular bone tissue. Because metatarsals and metacarpals are composed of trabecular epiphyses and a dense diaphysis, the goal of this study was to explore intra-bone variability in DNA content by measuring nuclear DNA quantity and quality using the PowerQuant System (Promega). A total of 193 bones from a single Second World War mass grave were examined. From each bone, DNA was extracted from the compact diaphysis and from both spongy epiphyses combined. This study confirms higher DNA quantity in epiphyses than diaphyses among all the bones analyzed, and more DNA was obtained from metacarpal epiphyses than from metatarsal epiphyses. Therefore, whenever the possibility for sampling both metacarpals and metatarsals from skeletal remains exists, collecting metacarpals is recommended. In cases in which the hands are missing, metatarsals should be sampled. In any case, epiphyses are a richer source of DNA than diaphyses.
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