Evidence map›Paper›PMID 33623834›Full record

ArticleComputational toxicology (Amsterdam, Netherlands)2019

Transitioning the Generalised Read-Across approach (GenRA) to quantitative predictions: A case study using acute oral toxicity data.

George Helman, Imran Shah, Grace Patlewicz

Abstract read
In one paragraph

Article in Computational toxicology (Amsterdam, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Towards systematic read-across using Generalised Read-Across (GenRA).Computational toxicology (Amsterdam, Netherlands) · 2023
    Article
  5. Review
  6. Evaluation of Variability Across Rat Acute Oral Systemic Toxicity Studies.Toxicological sciences : an official journal of the Society of Toxicology · 2022
    Article
  7. Article
  8. Article
  9. Generalized Read-Across prediction using genra-py.Bioinformatics (Oxford, England) · 2021
    Article
  10. Article
  11. Article
  12. Quantitative prediction of repeat dose toxicity values using GenRA.Regulatory toxicology and pharmacology : RTP · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

George HelmanOak Ridge Institute for Science and Education (ORISE), Oak Ridge, Tennessee, USA.
Imran ShahNational Center for Computational Toxicology (NCCT), Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Dr, Research Triangle Park (RTP), NC 27711, USA.
Grace PatlewiczNational Center for Computational Toxicology (NCCT), Office of Research and Development, US Environmental Protection Agency, 109 TW Alexander Dr, Research Triangle Park (RTP), NC 27711, USA.

Funding

Intramural EPA EPA999999
6 · The paper itself

Abstract

Read-across approaches continue to evolve as does their utility in the field of risk assessment. Previously we presented our generalised read-across (GenRA) approach (Shah et al., 2016), which utilises chemical descriptor and/or

Indexed as

acute oral toxicityGeneralized read-across (GenRA)quantitative predictions

Identifiers

PMID33623834
PMCPMC7898163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.