ArticleClinical kidney journal2021
Net ultrafiltration rate and its impact on mortality in patients with acute kidney injury receiving continuous renal replacement therapy.
Article in Clinical kidney journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05306964 (REstrictive Versus LIberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury), which is not on this map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
REstrictive Versus LIberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury
Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Clinical practice guideline for renal replacement therapy in critically ill patients with acute kidney injury (2026 edition).Journal of intensive medicine · 2026Article
- Ultrafiltration in the critically ill patient: a framework for personalized care.Critical care (London, England) · 2026Review
- Early net ultrafiltration thresholds and mortality in critically ill patients with septic acute kidney injury receiving continuous renal replacement therapy.Renal failure · 2025Article
- The prognostic impact of net ultrafiltration intensity in critically ill patients receiving continuous renal replacement therapy: a multivariable and propensity-matched analysis.Renal failure · 2025Observational
- Saline flushing to prevent circuit clotting during CRRT without anticoagulant: a randomized controlled study.BMC nursing · 2025Article
- [The ROSE concept: modern fluid management in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Behind the scenes: Key lessons learned from the RELIEVE-AKI clinical trial.Journal of critical care · 2024Review
- Kidney Injury in Critically Ill Patients with COVID-19 - From Pathophysiological Mechanisms to a Personalized Therapeutic Model.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023Review
- Fluid Overload and Precision Net Ultrafiltration in Critically Ill Patients.Cardiorenal medicine · 2023Review
- Continuous Kidney Replacement Therapy Practices in Pediatric Intensive Care Units Across Europe.JAMA network open · 2022Article
- Farewell from theClinical kidney journal · 2022Article
- Prediction of hemodynamic tolerance of intermittent hemodialysis in critically ill patients: a cohort study.Scientific reports · 2021Observational
- ["Intravascular space contracted-tissue space expanded": interstitial edema and fluid management in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2021Review
- Early restrictive fluid balance is associated with lower hospital mortality independent of acute disease severity in critically ill patients on CRRT.Scientific reports · 2021Article
- Ultrafiltration in critically ill patients treated with kidney replacement therapy.Nature reviews. Nephrology · 2021Review
- A Case Series: Continuous Kidney Replacement Therapy in Neonates With Low Body Weight.Frontiers in pediatrics · 2021Article
- The Association of an Early Net Ultrafiltration Rate and 28-Day Mortality in Patients Receiving Continuous Kidney Replacement Therapy.Frontiers in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluid overload, a critical consequence of acute kidney injury (AKI), is associated with worse outcomes. The optimal fluid removal rate per day during continuous renal replacement therapy (CRRT) is unknown. The purpose of this study is to evaluate the impact of the ultrafiltration rate on mortality in critically ill patients with AKI receiving CRRT.
methodsThis was a retrospective cohort study where we reviewed 1398 patients with AKI who received CRRT between December 2006 and November 2015 at the Mayo Clinic, Rochester, MN, USA. The net ultrafiltration rate (UF
resultsThe mean ± SD age was 62 ± 15 years, and 827 (59%) were male. There were 696 patients (49.7%) in the low- and 702 (50.2%) in the high-intensity group. Thirty-day mortality was 755 (54%). There were 420 (60%) deaths in the low-, and 335 (48%) in the high-intensity group (P < 0.001). UF
conclusionsMore intensive fluid removal, UF
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.