Evidence map›Paper›PMID 33623635›Full record

ArticleOxidative medicine and cellular longevity2021

Hormone Replacement Therapy and Aging: A Potential Therapeutic Approach for Age-Related Oxidative Stress and Cardiac Remodeling.

Renáta Szabó, Alexandra Hoffmann, Denise Börzsei, Krisztina Kupai, Médea Veszelka, Anikó Magyariné Berkó, Imre Pávó, Rudolf Gesztelyi, Béla Juhász, Zsolt Turcsán and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Renáta SzabóDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0001-7881-2082
Alexandra HoffmannDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0003-4105-9298
Denise BörzseiDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-7899-9374
Krisztina KupaiDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-0644-1718
Médea VeszelkaDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0003-2037-3288
Anikó Magyariné BerkóDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-1237-5745
Imre PávóDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Rudolf GesztelyiDepartment of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen H-4032, Hungary.ORCID https://orcid.org/0000-0001-7911-055X
Béla JuhászDepartment of Pharmacology and Pharmacotherapy, University of Debrecen, Debrecen H-4032, Hungary.ORCID https://orcid.org/0000-0001-8878-5153
Zsolt TurcsánDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.
Anikó PósaDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0003-2167-2888
Csaba VargaDepartment of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged H-6726, Hungary.ORCID https://orcid.org/0000-0002-2678-665X
University of Szeged · HUUniversity of Debrecen · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advanced age is an independent risk factor for cardiovascular diseases, which might be further exacerbated by estrogen deficiency. Hormone replacement therapy (HRT) decreases cardiovascular risks and events in postmenopausal women; however, its effects are not fully elucidated in older individuals. Thus, the aim of our study is to examine the impact of HRT on oxidant/antioxidant homeostasis and cardiac remodeling. In our experiment, control (fertile) and aging (~20-month-old) female Wistar rats were used. Aging rats were further divided into estrogen- (E

Indexed as

Hormone Replacement TherapyOxidative StressVentricular RemodelingAgingAnimalsCollagen Type IEstrogensFemaleGlutathioneHeme Oxygenase (Decyclizing)Matrix Metalloproteinase 2MyocardiumRaloxifene HydrochlorideRatsRats, WistarCollagen Type IEstrogensGlutathioneHeme Oxygenase (Decyclizing)Matrix Metalloproteinase 2Raloxifene Hydrochloride

Identifiers

PMID33623635
PMCPMC7875635
OpenAlexW3129146415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.