ArticleCancer management and research2021
Risk Factors and Prediction Model for Lateral Lymph Node Metastasis of Papillary Thyroid Carcinoma in Children and Adolescents.
Article in Cancer management and research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.
- 2022 European Thyroid Association Guidelines for the management of pediatric thyroid nodules and differentiated thyroid carcinoma.European thyroid journal · 2022Guideline
- Extrathyroidal extension is independently associated with cervical lymph node metastasis in pediatric papillary thyroid carcinoma.Archives of endocrinology and metabolism · 2026Article
- Central lymph node ratio predicting lateral metastasis in pediatric thyroid cancer: a retrospective study.Frontiers in endocrinology · 2026Article
- Article
- Prediction model for lateral lymph node metastasis of papillary thyroid carcinoma in children and adolescents based on ultrasound imaging and clinical features: a retrospective study.BMC medical imaging · 2024Article
- Association of serum 25-hydroxyvitamin D levels with aggressiveness of papillary thyroid cancer.Endocrine connections · 2024Article
- Comparison of ultrasonography and pathology features between children and adolescents with papillary thyroid carcinoma.Heliyon · 2023Article
- Predictive Factors for Recurrence of Papillary Thyroid Carcinoma in Children and Adolescents.Frontiers in oncology · 2022Article
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8 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
purposePapillary thyroid carcinoma (PTC) in children and adolescents is prone to lateral lymph node metastasis (LNM), which is a high-risk factor for recurrence. However, few studies focused on identifying risk factors and establishing prediction models for lateral LNM of PTC in children and adolescents. PATIENTS AND
methodsWe retrospectively reviewed consecutive cases of children and adolescents with PTC undergoing thyroidectomy and cervical lymph node dissection between January 2009 and December 2019. The demographics and clinicopathologic features were collected and analyzed.
resultsA total of 102 children and adolescents with PTC were enrolled in our study; 51 of whom had lateral LNM (50%). After adjusting for other risk factors, the independent risk factors for lateral LNM were multifocality (odds ratio [OR]: 6.04; 95% confidence interval [CI]: 1.653-22.092; p=0.007), tumor size (OR: 1.752; 95% CI: 1.043-2.945; p=0.034), and the number of central LNM (OR: 1.23; 95% CI: 1.028-1.472; p=0.023). The formula of the combined predictor is: Multifocality + 0.31 × Tumor size + 0.115 × Number of central LNM. The area under the receiver operating characteristic curve of multifocality, tumor size, number of central LNM, and the combined predictor was 0.706, 0.762, 0.748, and 0.855, respectively. When the value of the combined predictor was ≥2.2744, lateral LNM could be predicted. The sensitivity and specificity of the predicted value were 82.4% and 74.5%, respectively.
conclusionThe independent risk factors for lateral LNM in children and adolescents with PTC were multifocality, tumor size, and the number of central LNM. The prediction model can better predict the presence of lateral LNM.
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