Evidence map›Paper›PMID 33623398›Full record

ArticleInfection and drug resistance2021

Drug Resistance Conferring Mutation and Genetic Diversity of

Sosina Ayalew, Teklu Wegayehu, Hawult Taye, Liya Wassie, Selfu Girma, Stefan Berg, Adane Mihret

Open access · goldAbstract read
In one paragraph

Article in Infection and drug resistance, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Genetic diversity ofNew microbes and new infections · 2024
    Article
  4. Article
  5. Genetic diversity ofHeliyon · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Infection and drug resistance · 2023
    Article
  10. Frequency of rpoB, katG, and inhA Gene Polymorphisms Associated with Multidrug-ResistantInterdisciplinary perspectives on infectious diseases · 2022
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sosina AyalewArmauer Hansen Research Institute, Addis Ababa, Ethiopia.ORCID 0000-0001-5276-7236
Teklu WegayehuDepartment of Biology, College of Natural Sciences, Arba Minch University (AMU), Arba Minch, Ethiopia.
Hawult TayeArmauer Hansen Research Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-5604-9706
Liya WassieArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Selfu GirmaArmauer Hansen Research Institute, Addis Ababa, Ethiopia.ORCID 0000-0002-1866-0950
Stefan BergBacteriology Department, Animal and Plant Health Agency, Weybridge, UK.
Adane MihretArmauer Hansen Research Institute, Addis Ababa, Ethiopia.
Armauer Hansen Research Institute · ETAnimal and Plant Health Agency · GBArba Minch University · ET

Funding

Ethiopia-Emory TB Research Training ProgramD43TW009127 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Kidist Bobosha · 2013 to 2026
$3.4M
FIC NIH HHS D43 TW009127
6 · The paper itself

Abstract

backgroundTuberculosis lymphadenitis (TBLN) is a growing public health concern in Ethiopia. However, there is limited information available on gene mutations conferring drug resistance and genetic diversity of

methodsDrug resistance and genetic diversity analysis were done on 91

resultsOut of the 91 strains, mutations conferring resistance to rifampicin (RIF) and isoniazid (INH) were observed in two (2.2%) and six (6.6%) isolates, respectively. The two RIF resistant isolates displayed a mutation at codon 531 in the

conclusionThe detection of drug resistant conferring mutation in treatment naïve TBLN patients together with detection of drug resistant isolates among clustered strains might suggest resistant strains' transmission in the community. This needs to be carefully considered to prevent the spread of drug resistant clones in the country.

Indexed as

drug resistantgenetic diversitymutationtuberculosis lymphadenitis

Identifiers

PMID33623398
PMCPMC7894881
OpenAlexW3129504344

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.