ArticleInternational journal of clinical pediatric dentistry
Effectiveness of Self-assembling Peptide P
Article in International journal of clinical pediatric dentistry. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07664046 (A Three-arm Randomized Controlled Trial Evaluating the Effectiveness of Self- Assembling Peptide P11-4 in the Remineralization of Enamel Carious White Spot Lesions), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Three-arm Randomized Controlled Trial Evaluating the Effectiveness of Self- Assembling Peptide P11-4 in the Remineralization of Enamel Carious White Spot Lesions
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Comparison of therapies of white spot lesions: a systematic review and network meta-analysis.BMC oral health · 2023Pooled it
- Evaluation of the remineralization potential of self-assembling peptide P11-4 with fluoride compared to fluoride varnish in the management of incipient carious lesions: a randomized controlled clinical trial.Clinical oral investigations · 2024Trial
- Evaluation of the remineralizing effect of biomimetic self-assembling peptides in post-orthodontic white spot lesions compared to fluoride-based delivery systems: randomized controlled trial.Clinical oral investigations · 2023Trial
- Three-arm randomized controlled trial evaluating the effectiveness of the self-assembling peptide P11-4 in the remineralization of enamel carious white spot lesions: a study protocol.Frontiers in oral health · 2026Article
- Evaluating the remineralisation potential and clinical evidence of emerging biocompatible materials in restorative dentistry: a systematic review.Biomaterial investigations in dentistry · 2026Review
- Review
- Article
- Evaluation of the effect of self-assembling peptide and fluoride varnish, alone or in combination with laser irradiation, on artificial enamel caries: a SEM/EDS and Micro-CT study.Clinical oral investigations · 2024Article
- White Spot Lesions in Fixed Orthodontics: A Literature Review on Etiology, Prevention, and Treatment.Cureus · 2024Review
- Biomimetic Enamel Regeneration Using Self-Assembling Peptide PBiomimetics (Basel, Switzerland) · 2023Review
- Analysis of Dental Enamel Remineralization: A Systematic Review of Technique Comparisons.Bioengineering (Basel, Switzerland) · 2023Review
- Effect of a Self-Assembly Peptide on Surface Roughness and Hardness of Bleached Enamel.Journal of functional biomaterials · 2022Article
- Effectiveness of Self-Assembling Peptide (P11-4) in Dental Hard Tissue Conditions: A Comprehensive Review.Polymers · 2022Review
- Remineralization of early enamel caries lesions using self-assembling peptides PJournal of oral biology and craniofacial researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluoride varnish with therapeutic tricalcium phosphate formulas such as Clinpro™ varnish has shown greater tendency in treating white spot lesions (WSLs) by inhibiting the progression of initial enamel lesions through the mineral exchange. The self-assembling peptide SAP
aimTo quantitatively and qualitatively compare the effectiveness of the SAP MATERIALS AND
methodsNine healthy patients were enrolled in this study. The trial was performed on 40 young permanent teeth in the initial demineralization stage. Teeth were randomly assigned to receive either TCPF (group I) or SAP
resultsThe result of the current study revealed a significant quantitative and qualitative increase in remineralization of WSLs in both groups and over time intervals. However, the WSL recovery was significantly better in the self-assembling peptide group, reflecting an excellent remineralization potential of the WSLs by the SAP
conclusionBoth TCPF and SAP CLINICAL SIGNIFICANCE: Early detection of WSLs and minimal intervention through remineralizing agents can limit unnecessary tissue loss, further caries progression, and consequently prevent further harm to the patients. HOW TO CITE THIS ARTICLE: Kobeissi R, Badr SBY, Osman E. Effectiveness of Self-assembling Peptide P
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.