ArticleJournal of conservative dentistry : JCD
Comparative analysis of platelet-rich fibrin, platelet-rich fibrin with hydroxyapatite and platelet-rich fibrin with alendronate in bone regeneration: A cone-beam computed tomography analysis.
Article in Journal of conservative dentistry : JCD. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Volumetric Assessment of Apical Periodontitis Using Cone-Beam Computed Tomography-A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Clinical Outcomes of Platelet-Rich Fibrin in Endodontic Microsurgery: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Context-dependent effectiveness of autologous platelet concentrates in regenerative endodontic procedures and periapical surgery: A systematic review and meta-analysis.Journal of conservative dentistry and endodontics · 2026Review
- Two-dimensional and three-dimensional evaluation of bone regeneration using platelet-rich fibrin versus bone putty in large periapical lesions after endodontic surgery: A randomized clinical trial.Journal of conservative dentistry and endodontics · 2026Article
- Enriched advanced platelet-rich fibrin plus gold nanoparticles againstJournal of conservative dentistry and endodontics · 2024Article
- Influence of periapical lesion volume on the radiodensity of surrounding bone: A CBCT study.Journal of conservative dentistry and endodontics · 2024Article
- Leukocyte-Platelet-Rich Fibrin in Bone Regeneration after Periapical Surgery: A 30-Month Follow-Up Clinical Report.Reports (MDPI) · 2024Article
- Navigating the combinations of platelet-rich fibrin with biomaterials used in maxillofacial surgery.Frontiers in bioengineering and biotechnology · 2024Review
- Analysis of the effects of concentrated growth factor and low-level laser therapy on the bone healing.Heliyon · 2023Article
- Effect of platelet-rich fibrin on periapical healing and resolution of clinical symptoms in patients following periapical surgery: A systematic review and meta-analysis.Journal of conservative dentistry and endodonticsReview
- Clinicoradiographic evaluation of polymer of injectable platelet rich fibrin (i-PRF) and hydroxyapatite as bone graft substitute in maxillomandibular bony defects: A double blinded randomised control trial.National journal of maxillofacial surgeryArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis clinical study was designed to evaluate the volumetric healing of periapical (PA) bone defect after PA surgery, using platelet-rich fibrin (PRF), and its combination with hydroxyapatite and alendronate. SUBJECTS AND
methodsTwenty male patients of age between 25 and 35 years, having PA pathology (>5 mm on intraoral periapical radiograph (IOPA)) with intraoral sinus opening, were included in this study. Cone-beam computed tomography (CBCT) imaging of all patients was done. Root canal treatment with PA surgery was done. Patients were divided into four groups (5 in each group), on the basis of material placed in PA bone defect. After 1 year, CBCT imaging was done. Linear measurement of maximal dimensions in all three orthogonal planes was done in both pre- and post-CBCT image. These measurements were used to estimate the volume of the lesion healed after 1 year of surgery. STATISTICAL ANALYSIS: Analysis of variance and
resultsChange in volume were significantly different between Group 1 vs Group 3; Group 2 vs Group 3 and Group 3 vs Group 4. The Group Order for change in volume 1 year post surgery Group 3> Group 4 ≈ Group 2> Group 1.
conclusionsPA bone healing after surgery is enhanced by placing combination of bone regenerative materials. PRF with hydroxyapatite provides best healing outcomes in comparison to PRF with alendronate or PRF alone.
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Registered trials
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