ArticleScientific reports2021
Comparing different approaches for operationalizing subjective cognitive decline: impact on syndromic and biomarker profiles.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
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- Plasma and feces multiomics unveil cognition-associated perturbations of chronic inflammatory pathways of the gut-microbiota-brain axis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Subjective cognitive decline among diverse older adults: Prevalence and associations with objective cognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Subjective cognitive complaints and future risk of dementia and cognitive impairment, which matters most.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2025Article
- Loneliness and biomarkers of brain pathology in people with subjective cognitive decline.Scientific reports · 2025Article
- Neuropsychological Assessment for Early Detection and Diagnosis of Dementia: Current Knowledge and New Insights.Journal of clinical medicine · 2024Review
- Clinical predictors of Alzheimer's disease-like brain atrophy in individuals with memory complaints.Brain and behavior · 2024Article
- Biomarkers of Alzheimer's Disease and Cerebrovascular Disease in Relation to Depressive Symptomatology in Individuals With Subjective Cognitive Decline.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Subjective cognitive and olfactory impairments predict different prospective dementia outcomes.Chemical senses · 2024Article
- Spatial navigation is associated with subcortical alterations and progression risk in subjective cognitive decline.Alzheimer's research & therapy · 2023Article
- Subjective Cognitive Decline Is Associated With Lower Baseline Cognition and Increased Rate of Cognitive Decline.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Subjective Impairments in Olfaction and Cognition Predict Dissociated Behavioral Outcomes.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Examining the role of participant and study partner report in widely-used classification approaches of mild cognitive impairment in demographically-diverse community dwelling individuals: results from the Einstein aging study.Frontiers in aging neuroscience · 2023Article
- The Association Between Temporal Atrophy and Episodic Memory Is Moderated by Education in a Multi-Center Memory Clinic Sample.Journal of Alzheimer's disease : JAD · 2023Article
- Multimorbidity Patterns in US Adults with Subjective Cognitive Decline and Their Relationship with Functional Difficulties.Journal of aging and health · 2022Article
- Article
- Overall and sex-specific risk factors for subjective cognitive decline: findings from the 2015-2018 Behavioral Risk Factor Surveillance System Survey.Biology of sex differences · 2022Article
- The discriminant validity of single-question assessments of subjective cognitive complaints in an Asian older adult population.Frontiers in aging neuroscience · 2022Article
- The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline.Aging · 2021Article
- Cerebrovascular Disease and Depressive Symptomatology in Individuals With Subjective Cognitive Decline: A Community-Based Study.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subjective cognitive decline (SCD) has been proposed as a risk factor for future cognitive decline and dementia. Given the heterogeneity of SCD and the lack of consensus about how to classify this condition, different operationalization approaches still need to be compared. In this study, we used the same sample of individuals to compare different SCD operationalization approaches. We included 399 cognitively healthy individuals from a community-based cohort. SCD was assessed through nine questions about memory and non-memory subjective complaints. We applied four approaches to operationalize SCD: two hypothesis-driven approaches and two data-driven approaches. We characterized the resulting groups from each operationalization approach using multivariate methods on comprehensive demographic, clinical, cognitive, and neuroimaging data. We identified two main phenotypes: an amnestic phenotype characterized by an Alzheimer's Disease (AD) signature pattern of brain atrophy; and an anomic phenotype, which was mainly related to cerebrovascular pathology. Furthermore, language complaints other than naming helped to identify a subgroup with subclinical cognitive impairment and difficulties in activities of daily living. This subgroup also showed an AD signature pattern of atrophy. The identification of SCD phenotypes, characterized by different syndromic and biomarker profiles, varies depending on the operationalization approach used. In this study we discuss how these findings may be used in clinical practice and research.
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