Evidence map›Paper›PMID 33623069›Full record

ArticleScientific reports2021

Improved pentamethine cyanine nanosensors for optoacoustic imaging of pancreatic cancer.

Matthew D Laramie, Benjamin L Fouts, William M MacCuaig, Emmanuel Buabeng, Meredith A Jones, Priyabrata Mukherjee, Bahareh Behkam, Lacey R McNally, Maged Henary

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
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  9. Theranostic nanoparticles for detection and treatment of pancreatic cancer.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Matthew D Laramie *Department of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Benjamin L Fouts *Department of Surgery, Oklahoma Health Science Center, Oklahoma City, 73104, USA.
William M MacCuaigStephenson Cancer Center, Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.
Emmanuel BuabengDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA.
Meredith A JonesDepartment of Biomedical Engineering, University of Oklahoma, Norman, OK, 72073, USA.
Priyabrata MukherjeeDepartment of Pathology, Oklahoma Health Science Center, Oklahoma City, OK, 73104, USA.
Bahareh BehkamDepartment of Mechanical Engineering, Virginia Tech University, Blacksburg, VA, 24061, USA.
Lacey R McNallyDepartment of Surgery, Oklahoma Health Science Center, Oklahoma City, 73104, USA. lacey_mcnally@hotmail.com.
Maged HenaryDepartment of Chemistry, Georgia State University, Atlanta, GA, 30303, USA. mhenary1@gsu.edu.
Georgia State University · USUniversity of Oklahoma Health Sciences Center · USUniversity of Oklahoma · USVirginia Tech · US

Funding

Stroma Targeted Theranostic Nanoparticles for Pancreatic CancerR01CA212350 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2017 to 2021
$1.7M
Non-Invasive Detection of Tumor Extracellular pH using Multispectral Optoacoustic TomographyR01CA205941 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2021
$1.7M
Theranostic Nanoparticles For Detection and Treatment of Pancreatic CancerR01EB020125 · NIBIB · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MCNALLY, LACEY R · 2016 to 2019
$1.7M
NCI NIH HHS R01 CA205941NCI NIH HHS R01 CA212350NIBIB NIH HHS R01 EB020125
6 · The paper itself

Abstract

Optoacoustic imaging is a new biomedical imaging technology with clear benefits over traditional optical imaging and ultrasound. While the imaging technology has improved since its initial development, the creation of dedicated contrast agents for optoacoustic imaging has been stagnant. Current exploration of contrast agents has been limited to standard commercial dyes that have already been established in optical imaging applications. While some of these compounds have demonstrated utility in optoacoustic imaging, they are far from optimal and there is a need for contrast agents with tailored optoacoustic properties. The synthesis, encapsulation within tumor targeting silica nanoparticles and applications in in vivo tumor imaging of optoacoustic contrast agents are reported.

Indexed as

AnimalsBiosensing TechniquesCarbocyaninesContrast MediaFemaleMiceNanoparticlesPancreatic NeoplasmsPhotoacoustic TechniquesSilicon DioxideCarbocyaninesContrast MediaSilicon Dioxide

Identifiers

PMID33623069
PMCPMC7902650
OpenAlexW3131869340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.