ArticleNature communications2021
Polygenic hazard score is associated with prostate cancer in multi-ethnic populations.
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Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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37citing papers in PubMed, 1 pooled it
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Fully exploiting SNP arrays: a systematic review on the tools to extract underlying genomic structure.Briefings in bioinformatics · 2022Pooled it
- Unified genetic risk score for prostate cancer enables improved risk stratification for clinical decision-making.Journal of medical genetics · 2026Article
- Germline polygenic score for prostate cancer aggressiveness.medRxiv : the preprint server for health sciences · 2026Article
- Incorporating external risk information with the Cox model under population heterogeneity: applications to trans-ancestry polygenic hazard scores.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2026Article
- Joint Biochemical and Genetic Prostate Cancer Risk Stratification.The Journal of urology · 2026Article
- Polygenic risk and germline genetics for prostate cancer in Asians: Where do we stand?Investigative and clinical urology · 2026Review
- Genomic risk model to implement precision prostate cancer screening in clinical care: the ProGRESS study.Nature cancer · 2026Article
- Polygenic risk score (PRS) as prostate cancer screening: ready for primetime?Annals of translational medicine · 2025Article
- Racial disparity in prostate cancer: an outlook in genetic and molecular landscape.Cancer metastasis reviews · 2024Review
- Upgrading of Grade Group 1 Prostate Cancer at Prostatectomy: Germline Risk Factors in a Prospective Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Deficits of Molecular Prognosis/Diagnosis Studies in Underserved Populations.JCO oncology practice · 2024Review
- Predictive value of polygenic risk score for prostate cancer incidence and prognosis in the Han Chinese.Scientific reports · 2024Article
- A west African ancestry-associated SNP on 8q24 predicts a positive biopsy in African American men with suspected prostate cancer following PSA screening.The Prostate · 2024Article
- Integration of polygenic and gut metagenomic risk prediction for common diseases.Nature aging · 2024Article
- Ethnic differences in prostate cancer presentation: a time for testing advocacy.World journal of urology · 2023Article
- Racial disparity in the genomics of precision oncology of prostate cancer.Cancer reports (Hoboken, N.J.) · 2023Review
- Genetic risk assessment of lethal prostate cancer using polygenic risk score and hereditary cancer susceptibility genes.Journal of translational medicine · 2023Article
- Polygenic risk of any, metastatic, and fatal prostate cancer in the Million Veteran Program.Journal of the National Cancer Institute · 2023Article
- New insights from the last decade of research in psychiatric genetics: discoveries, challenges and clinical implications.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2023Article
- Polygenic risk score for tumor aggressiveness and early-onset prostate cancer in Asians.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
85 authors.
Minh-Phuong Huynh-LeDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-5025-4709
Chun Chieh FanCenter for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-9437-2128
Roshan KarunamuniDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA.
Wesley K ThompsonDivision of Biostatistics and Halicioğlu Data Science Institute, University of California San Diego, La Jolla, CA, USA.
Maria Elena MartinezMoores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA.
Rosalind A EelesThe Institute of Cancer Research, London, UK.ORCID 0000-0002-3698-6241
Zsofia Kote-JaraiThe Institute of Cancer Research, London, UK.
Kenneth MuirDivision of Population Health, Health Services Research and Primary Care, University of Manchester, Oxford Road, Manchester, UK.ORCID 0000-0001-6429-988X
Johanna SchleutkerInstitute of Biomedicine, Kiinamyllynkatu 10, FI-20014 University of Turku, Turku, Finland.ORCID 0000-0002-1863-0305
Nora PashayanUniversity College London, Department of Applied Health Research, London, UK.ORCID 0000-0003-0843-2468
Jyotsna BatraAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Queensland University of Technology, Brisbane, QLD, Australia.ORCID 0000-0003-4646-6247
Henrik GrönbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-1073-2753
David E NealNuffield Department of Surgical Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK.
Jenny L DonovanPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Richard M MartinPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.ORCID 0000-0002-7992-7719
Sune F NielsenFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Børge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-1954-7220
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.ORCID 0000-0002-4623-0544
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Graham G GilesCancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia.ORCID 0000-0003-4946-9099
Alicja WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-7387-6845
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Ruth C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-9571-0763
William J BlotDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID 0000-0003-1226-070X
Maureen SandersonDepartment of Family and Community Medicine, Meharry Medical College, Nashville, TN, USA.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Lorelei A MucciDepartment of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA.
Catharine M L WestDivision of Cancer Sciences, University of Manchester, Manchester Academic Health Science Centre, Radiotherapy Related Research, The Christie Hospital NHS Foundation Trust, Manchester, UK.ORCID 0000-0002-0839-3449
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, USA.
Olivier CussenotSorbonne Universite, GRC n°5, AP-HP, Tenon Hospital, 4 Rue de la Chine, Paris, France.
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, USA.
Karina Dalsgaard SørensenDepartment of Molecular Medicine, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-4902-5490
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Florence MenegauxCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, Villejuif Cédex, France.
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, UK.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.ORCID 0000-0002-6384-6447
Sue A InglesDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Christiane MaierHumangenetik Tuebingen, Tuebingen, Germany.
Robert J HamiltonDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, Canada.
Stephen N ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Barry S RosensteinDepartment of Radiation Oncology and Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, USA.
Yong-Jie LuCentre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, John Vane Science Centre, Charterhouse Square, London, UK.
Stephen WatyaUro Care, Kampala, Uganda.
Ana VegaFundación Pública Galega Medicina Xenómica, Santiago De Compostela, Spain.ORCID 0000-0002-7416-5137
Manolis KogevinasISGlobal, Barcelona, Spain.
Kathryn L PenneyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
Chad HuffThe University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute of Porto (IPO-Porto), Porto, Portugal.ORCID 0000-0002-4896-5982
Luc MultignerUniv Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail)-UMR_S 1085, Rennes, France.ORCID 0000-0003-3205-8568
Robin J LeachDepartment of Urology, Mays Cancer Center, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Lisa Cannon-AlbrightDivision of Epidemiology, Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA.ORCID 0000-0003-2602-3668
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Esther M JohnDepartment of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Radka KanevaMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, Sofia, Bulgaria.
Christopher J LogothetisThe University of Texas M. D. Anderson Cancer Center, Department of Genitourinary Medical Oncology, Houston, TX, USA.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, USA.
Kim De RuyckGhent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, Gent, Belgium.
Hardev PandhaThe University of Surrey, Guildford, Surrey, UK.
Azad RazackDepartment of Surgery, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
Lisa F NewcombDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jay H FowkeDepartment of Medicine and Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.
Marija GamulinDepartment of Oncology, University Hospital Centre Zagreb, University of Zagreb, School of Medicine, Zagreb, Croatia.ORCID 0000-0003-2431-7910
Nawaid UsmaniDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, Alberta, Canada.
Frank ClaessensDepartment of Cellular and Molecular Medicine, Molecular Endocrinology Laboratory, KU Leuven, Leuven, Belgium.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, Santiago de Compostela, Spain.
Paul A TownsendDivision of Cancer Sciences, Manchester Cancer Research Centre, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, UK.
William S BushCase Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland Institute for Computational Biology, Cleveland, OH, USA.ORCID 0000-0002-9729-6519
Monique J RoobolDepartment of Clinical Chemistry, Erasmus University Medical Center, Rotterdam, The Netherlands.ORCID 0000-0001-6967-1708
Marie-Élise ParentEpidemiology and Biostatistics Unit, Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, QC, Canada.
Jennifer J HuThe University of Miami School of Medicine, Sylvester Comprehensive Cancer Center, Miami, FL, USA.
Ian G MillsNuffield Department of Surgical Sciences, University of Oxford, Oxford, UK.
Ole A AndreassenNORMENT, KG Jebsen Centre, Oslo University Hospital and University of Oslo, Oslo, Norway.ORCID 0000-0002-4461-3568
Anders M DaleCenter for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.
Tyler M SeibertDepartment of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, CA, USA. tseibert@ucsd.edu.ORCID 0000-0002-4089-7399
UKGPCS collaborators
APCB (Australian Prostate Cancer BioResource)
NC-LA PCaP Investigators
IMPACT Study Steering Committee and Collaborators
Canary PASS Investigators
Profile Study Steering Committee
PRACTICAL Consortium
Funding
SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2MSWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6MPCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4MImproving assessment of prostate cancer bone metastases using advanced diffusion imagingK08EB026503 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEIBERT, TYLER MICHAEL · 2019 to 2022
$805kCancer Research UK 19169Cancer Research UK 29017Cancer Research UK 29019Cancer Research UK C11043/A4286Cancer Research UK C18281/A11326Cancer Research UK C18281/A15064Cancer Research UK C18281/A19169Cancer Research UK C18281/A24432Cancer Research UK C18281/A8145Department of HealthNCI NIH HHS U01 CA182883NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NIBIB NIH HHS K08 EB026503
Abstract
Genetic models for cancer have been evaluated using almost exclusively European data, which could exacerbate health disparities. A polygenic hazard score (PHS
Indexed as
AgedEthnicityHumansMaleMiddle AgedMultifactorial InheritanceMultivariate AnalysisNeoplasm InvasivenessProstatic NeoplasmsSelf Report
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