ArticleNature communications2021
Enantioselective construction of six- and seven-membered triorgano-substituted silicon-stereogenic heterocycles.
Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Construction of Medium-Sized Benzodisilacycles via Palladium-Catalyzed Intermolecular C(spJACS Au · 2026Article
- Rh-catalyzed enantioselective hydrosilylation of unactivated alkenes.Chemical science · 2025Article
- Iron-catalyzed sequential hydrosilylation.Nature communications · 2025Article
- Carbon-silicon-switch effect in enantioselective construction of silicon-stereogenic center from silacyclohexadienones.Nature communications · 2024Article
- Theoretical study on ligand conformational self-adaptation for modulating reactivity.Scientific reports · 2024Article
- Organocatalytic asymmetric synthesis of Si-stereogenic silacycles.Nature communications · 2024Article
- Stereospecific synthesis of silicon-stereogenic optically active silylboranes and general synthesis of chiral silyl Anions.Nature communications · 2023Article
- An unusual autocatalysis with an air-stable Pd complex to promote enantioselective synthesis of Si-stereogenic enynes.Chemical science · 2023Article
- Regioselective Ni-Catalyzed reductive alkylsilylation of acrylonitrile with unactivated alkyl bromides and chlorosilanes.Nature communications · 2022Article
- Chemo- and regioselective benzylic C(spiScience · 2022Article
- Rhodium hydride enabled enantioselective intermolecular C-H silylation to access acyclic stereogenic Si-H.Nature communications · 2022Article
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Authors and funding
6 authors.
Funding
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Abstract
The exploitation of chirality at silicon in asymmetric catalysis is one of the most intriguing and challenging tasks in synthetic chemistry. In particular, construction of enantioenriched mediem-sized silicon-stereogenic heterocycles is highly attractive, given the increasing demand for the synthesis of novel functional-materials-oriented silicon-bridged compounds. Here, we report a rhodium-catalyzed enantioselective construction of six- and seven-membered triorgano-substituted silicon-stereogenic heterocycles. This process undergoes a direct dehydrogenative C-H silylation, giving access to a wide range of triorgano-substituted silicon-stereogenic heterocycles in good to excellent yields and enantioselectivities, that significantly enlarge the chemical space of the silicon-centered chiral molecules. Further elaboration of the chiral monohydrosilane product delivers various corresponding tetraorgano-substituted silicon-stereogenic heterocycles without the loss of enantiopurity. These silicon-bridged heterocycles exhibit bright blue fluorescence, which would have potential application prospects in organic optoelectronic materials.
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