Evidence map›Paper›PMID 33623008›Full record

ArticleNature communications2021

Climate predicts geographic and temporal variation in mosquito-borne disease dynamics on two continents.

Jamie M Caldwell, A Desiree LaBeaud, Eric F Lambin, Anna M Stewart-Ibarra, Bryson A Ndenga, Francis M Mutuku, Amy R Krystosik, Efraín Beltrán Ayala, Assaf Anyamba, Mercy J Borbor-Cordova and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed.

  1. Review
  2. Climate-driven host ecology as a framework for zoonotic disease risk: Understanding transferability across arenavirus systems.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  17. Variations in annual dengue intensities are explained by temperature anomalies.medRxiv : the preprint server for health sciences · 2025
    Article
  18. Article
  19. Review
  20. Article

18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Jamie M CaldwellDepartment of Biology, Stanford University, Stanford, CA, USA. jamie.sziklay@gmail.com.ORCID 0000-0002-6220-918X
A Desiree LaBeaudDepartment of Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.ORCID 0000-0001-8364-6867
Eric F LambinSchool of Earth, Energy & Environmental Sciences, and Woods Institute for the Environment, Stanford University, Stanford, CA, USA.
Anna M Stewart-IbarraDepartment of Medicine and Department of Public Health and Preventative Medicine, SUNY Upstate Medical University, Syracuse, NY, USA.ORCID 0000-0002-3383-4672
Bryson A NdengaCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.ORCID 0000-0002-8445-2885
Francis M MutukuDepartment of Environment and Health Sciences, Technical university of Mombasa, Mombasa, Kenya.ORCID 0000-0002-9000-7008
Amy R KrystosikDepartment of Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.ORCID 0000-0001-7944-8876
Efraín Beltrán AyalaTechnical University of Machala, Machala, Ecuador.
Assaf AnyambaUniversities Space Research Association and NASA Goddard Space Flight Center, Greenbelt, MD, USA.
Mercy J Borbor-CordovaFacultad de Ingeniería Marítima y Ciencias del Mar, Escuela Superior Politécnica del Litoral, ESPOL, Guayaquil, Ecuador.ORCID 0000-0002-7418-141X
Richard DamoahMorgan State University and NASA Goddard Space Flight Center, Greenbelt, MD, USA.ORCID 0000-0003-0756-4362
Elysse N Grossi-SoysterDepartment of Pediatrics, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
Froilán Heras HerasCenter for Research SUNY-Upstate-Teófilo Dávila Hospital, Machala, Ecuador.
Harun N NgugiDepartment of Biological Sciences, Chuka University, Chuka, Kenya.
Sadie J RyanEmerging Pathogens Institute, University of Florida, Gainesville, FL, USA.ORCID 0000-0002-4308-6321
Melisa M ShahDepartment of Medicine, Division of Infectious Diseases, Stanford University, Stanford, CA, USA.
Rachel SippyCenter for Research SUNY-Upstate-Teófilo Dávila Hospital, Machala, Ecuador.ORCID 0000-0003-3617-2093
Erin A MordecaiDepartment of Biology, Stanford University, Stanford, CA, USA.ORCID 0000-0002-4402-5547

Funding

The child health impacts of overlapping vector-borne diseases in KenyaR01AI102918 · NIAID · STANFORD UNIVERSITY · PI Angelle Desiree LaBeaud · 2013 to 2026
$7.7M
Leveraging environmental drivers to predict vector-borne disease transmissionR35GM133439 · NIGMS · STANFORD UNIVERSITY · PI Erin Mordecai · 2019 to 2026
$3.2M
NIAID NIH HHS R01 AI102918NIGMS NIH HHS R35 GM133439
6 · The paper itself

Abstract

Climate drives population dynamics through multiple mechanisms, which can lead to seemingly context-dependent effects of climate on natural populations. For climate-sensitive diseases, such as dengue, chikungunya, and Zika, climate appears to have opposing effects in different contexts. Here we show that a model, parameterized with laboratory measured climate-driven mosquito physiology, captures three key epidemic characteristics across ecologically and culturally distinct settings in Ecuador and Kenya: the number, timing, and duration of outbreaks. The model generates a range of disease dynamics consistent with observed Aedes aegypti abundances and laboratory-confirmed arboviral incidence with variable accuracy (28-85% for vectors, 44-88% for incidence). The model predicted vector dynamics better in sites with a smaller proportion of young children in the population, lower mean temperature, and homes with piped water and made of cement. Models with limited calibration that robustly capture climate-virus relationships can help guide intervention efforts and climate change disease projections.

Indexed as

Climate ChangeGeographyAnimalsBasic Reproduction NumberCulicidaeDisease OutbreaksEcuadorHumansKenyaModels, BiologicalNonlinear DynamicsSocioeconomic FactorsSpatio-Temporal AnalysisTime FactorsVector Borne Diseases

Identifiers

PMID33623008
PMCPMC7902664

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.