Evidence map›Paper›PMID 33622983›Full record

ArticleScience signaling2021

Control of ribosomal protein synthesis by the Microprocessor complex.

Xuan Jiang, Amit Prabhakar, Stephanie M Van der Voorn, Prajakta Ghatpande, Barbara Celona, Srivats Venkataramanan, Lorenzo Calviello, Chuwen Lin, Wanpeng Wang, Brian L Black and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science signaling, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  6. Article
  7. R-Loop Immunoprecipitation: A Method to Detect R-Loop Interacting Factors.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 2 countries.

Xuan JiangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-1422-1555
Amit PrabhakarCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Stephanie M Van der VoornCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0003-0934-3491
Prajakta GhatpandeCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Barbara CelonaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-5391-8155
Srivats VenkataramananDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-2507-401X
Lorenzo CalvielloDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-5600-0988
Chuwen LinCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.
Wanpeng WangCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-9971-895X
Brian L BlackCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-6664-8913
Stephen N FloorDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0002-9965-9694
Giorgio LagnaCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA.ORCID 0000-0001-9228-4554
Akiko HataCardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA. akiko.hata@ucsf.edu.ORCID 0000-0003-3784-1738
University of California, San Francisco · US

Funding

Identification of a novel modulator of Pulmonary Artery HypertensionR01HL132058 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HATA, AKIKO · 2016 to 2019
$2.5M
The impact of human RNA diversity on protein production and cell fateDP2GM132932 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FLOOR, STEPHEN NICHOLAS · 2018 to 2018
$2.4M
The role of the sub-endothelial niche in hemogenic endothelial specificationR01DK119621 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLACK, BRIAN L · 2019 to 2021
$870k
NHLBI NIH HHS R01 HL132058NIDDK NIH HHS R01 DK119621NIGMS NIH HHS DP2 GM132932
6 · The paper itself

Abstract

Ribosome biogenesis in eukaryotes requires the coordinated production and assembly of 80 ribosomal proteins and four ribosomal RNAs (rRNAs), and its rate must be synchronized with cellular growth. Here, we showed that the Microprocessor complex, which mediates the first step of microRNA processing, potentiated the transcription of ribosomal protein genes by eliminating DNA/RNA hybrids known as R-loops. Nutrient deprivation triggered the nuclear export of Drosha, a key component of the Microprocessor complex, and its subsequent degradation by the E3 ubiquitin ligase Nedd4, thereby reducing ribosomal protein production and protein synthesis. In mouse erythroid progenitors, conditional deletion of

Indexed as

Protein BiosynthesisRibosomesAnimalsErythropoiesisMiceRibosomal ProteinsRNA, RibosomalRibosomal ProteinsRNA, Ribosomal

Identifiers

PMID33622983
PMCPMC8012103
OpenAlexW3132793418

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.