ArticleIn vivo (Athens, Greece)
Combination Cancer Therapy of a Del1 Fragment and Cisplatin Enhanced Therapeutic Efficiency
Article in In vivo (Athens, Greece). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The Employment of GeneraNutrients · 2022Review
- The EGF Motif With CXDXXXXYXCXC Sequence Suppresses Fibrosis in a Mouse Skin Wound Model.In vivo (Athens, Greece)Article
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimCombination cancer therapy is currently under investigation. This study examined the effect of cancer combination therapy using the E3 and C1 (E3C1) domains of developmental endothelial locus-1 (Del1) and cisplatin (CDDP) in murine transplanted tumors. MATERIALS AND
methodsMice with transplanted tumors (A431, SCCKN or SCC-4 cells) were injected intraperitoneally with CDDP and injected locally with nonviral plasmid vectors encoding E3C1. Histochemical analysis of the transplanted tumors was then performed to assess the effects on prognosis.
resultsThe CDDP+E3C1 injected group had reduced tumor growth and longer survival compared to the CDDP injected group. In addition, cell death was observed in the tumor of the CDDP+E3C1 group.. Furthermore, angiogenesis and increased blood vessels were observed together with stromal development.
conclusionThe CDDP+E3C1 treatment resulted in improved survival and poor tumor stromal development in mice with transplanted tumors.
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