Evidence map›Paper›PMID 33622790›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2021

Heritability of individualized cortical network topography.

Kevin M Anderson, Tian Ge, Ru Kong, Lauren M Patrick, R Nathan Spreng, Mert R Sabuncu, B T Thomas Yeo, Avram J Holmes

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.

  1. Pooled it
  2. Individualized Network Topography in Pre-adolescent Children and Adults Using Naturalistic Precision fMRI.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
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  11. Genetic contributions to brain criticality and its relationship with human cognitive functions.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Kevin M AndersonDepartment of Psychology, Yale University, New Haven, CT 06520; kevin.anderson@yale.edu.ORCID 0000-0002-9446-7386
Tian GePsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114.
Ru KongDepartment of Electrical and Computer Engineering, Centre for Sleep and Cognition, National University of Singapore, Singapore 119077.ORCID 0000-0001-7842-0329
Lauren M PatrickDepartment of Psychology, Yale University, New Haven, CT 06520.ORCID 0000-0002-7432-7802
R Nathan SprengDepartment of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 0G4, Canada.ORCID 0000-0003-1530-8916
Mert R SabuncuSchool of Electrical and Computer Engineering, Cornell University, Ithaca, NY 14850.
B T Thomas YeoDepartment of Electrical and Computer Engineering, Centre for Sleep and Cognition, National University of Singapore, Singapore 119077.ORCID 0000-0002-0119-3276
Avram J HolmesDepartment of Psychology, Yale University, New Haven, CT 06520.ORCID 0000-0001-6583-803X
National University of Singapore · SGYale University · USBroad Institute · USCornell University · USHarvard University · USMontreal Neurological Institute and Hospital · CA

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
SOLAR-Eclipse Computational Tools for Imaging GeneticsR01EB015611 · NIBIB · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOCHUNOV, PETER V. · 2012 to 2024
$5.0M
Functional genomics of the human connectome in psychiatric illnessR01MH120080 · NIMH · YALE UNIVERSITY · PI AVRAM J HOLMES, Thomas Boon Thye Yeo · 2019 to 2026
$4.8M
Advanced machine learning algorithms that integrate genomewide, longitudinal MRI and demographic data to predict future cognitive decline toward dementiaR01AG053949 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI SABUNCU, MERT RORY · 2017 to 2021
$2.4M
Novel Bioinformatics Strategies to Study Associations Between Genetic Variants and Neuroanatomical ShapeR01LM012719 · NLM · CORNELL UNIVERSITY · PI SABUNCU, MERT RORY · 2017 to 2020
$1.4M
Exploring the genetic basis of AD progressionR00AG054573 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2020 to 2022
$732k
Exploring the genetic basis of AD progressionK99AG054573 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI GE, TIAN · 2017 to 2018
$274k
NIA NIH HHS K99 AG054573NIA NIH HHS R00 AG054573NIA NIH HHS R01 AG053949NIBIB NIH HHS R01 EB015611NIMH NIH HHS R01 MH120080NIMH NIH HHS U54 MH091657NLM NIH HHS R01 LM012719
6 · The paper itself

Abstract

Human cortex is patterned by a complex and interdigitated web of large-scale functional networks. Recent methodological breakthroughs reveal variation in the size, shape, and spatial topography of cortical networks across individuals. While spatial network organization emerges across development, is stable over time, and is predictive of behavior, it is not yet clear to what extent genetic factors underlie interindividual differences in network topography. Here, leveraging a nonlinear multidimensional estimation of heritability, we provide evidence that individual variability in the size and topographic organization of cortical networks are under genetic control. Using twin and family data from the Human Connectome Project (

Indexed as

ConnectomeBrain MappingCerebral CortexHumansMagnetic Resonance ImagingModels, Theoreticalfunctional connectomefunction brain networksheritabilityindividualized parcellationresting-state

Identifiers

PMID33622790
PMCPMC7936334
OpenAlexW3131541338

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.