ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Parallel and Serial Sensory Processing in Developing Primary Somatosensory and Motor Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 54 citations in OpenAlex.
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- Large-FOV, dual-region, two-photon fluorescence lifetime imaging microscopy (LD-2P-FLIM) for multiparameter and quantitative brain function imaging.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Developmental Window-Dependent Effects of Neonatal Tactile Stimulation on Sensorimotor Development in WAG/Rij Rat Pups.Life (Basel, Switzerland) · 2026Article
- Motor cortex activity during sleep and wake movements sharpens across development but continues to lag the red nucleus.Scientific reports · 2026Article
- A transient feature of the inferior olive supports the development of cerebellar internal models.bioRxiv : the preprint server for biology · 2025Article
- Brain functional reorganization in pediatric patients with spinal cord injury and the impact of motor imagery training on it: a preliminary study.IBRO neuroscience reports · 2025Article
- Embodied sensorimotor control: computational modeling of the neural control of movement.ArXiv · 2025Article
- Training-Free Regulation of Grasping by Intracortical Tactile Feedback Designed via S1-M1 Communication.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Perinatal serotonin signalling dynamically influences the development of cortical GABAergic circuits with consequences for lifelong sensory encoding.Nature communications · 2025Article
- Elucidating Development Trajectories of Brain Functional Abnormalities in Major Depressive Disorder Utilizing a Data-Driven Disease Progression Model.Human brain mapping · 2025Article
- Motor Cortex Activation Patterns in Both Hemispheres Induced by Motor Imagery in Patients With Right- and Left-Sided Cerebral Infarction: An fNIRS Study.The European journal of neuroscience · 2025Article
- PTEN mutations impair CSF dynamics and cortical networks by dysregulating periventricular neural progenitors.Nature neuroscience · 2025Article
- More Than a Small Brain: The Importance of Studying Neural Function during Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Review
- Coincident development and synchronization of sleep-dependent delta in the cortex and medulla.Current biology : CB · 2024Article
- Spatiotemporal dynamics of cortical somatosensory network in typically developing children.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Alterations in cortical thickness and volumes of subcortical structures in pediatric patients with complete spinal cord injury.CNS neuroscience & therapeutics · 2024Article
- Developmentally Unique Cerebellar Processing Prioritizes Self- over Other-Generated Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Temporal Dynamics of Adverse Effects across Five Sessions of Transcranial Direct Current Stimulation.Brain sciences · 2024Article
- Bilateral Whisker Representations in the Primary Somatosensory Cortex in Robo3cKO Mice Are Reflected in the Primary Motor Cortex.Neuroscience · 2024Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
It is generally supposed that primary motor cortex (M1) receives somatosensory input predominantly via primary somatosensory cortex (S1). However, a growing body of evidence indicates that M1 also receives direct sensory input from the thalamus, independent of S1; such direct input is particularly evident at early ages before M1 contributes to motor control. Here, recording extracellularly from the forelimb regions of S1 and M1 in unanesthetized rats at postnatal day (P)8 and P12, we compared S1 and M1 responses to self-generated (i.e., reafferent) forelimb movements during active sleep and wake, and to other-generated (i.e., exafferent) forelimb movements. At both ages, reafferent responses were processed in parallel by S1 and M1; in contrast, exafferent responses were processed in parallel at P8 but serially, from S1 to M1, at P12. To further assess this developmental difference in processing, we compared exafferent responses to proprioceptive and tactile stimulation. At both P8 and P12, proprioceptive stimulation evoked parallel responses in S1 and M1, whereas tactile stimulation evoked parallel responses at P8 and serial responses at P12. Independent of the submodality of exafferent stimulation, pairs of S1-M1 units exhibited greater coactivation during active sleep than wake. These results indicate that S1 and M1 independently develop somatotopy before establishing the interactive relationship that typifies their functionality in adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.