Evidence map›Paper›PMID 33622706›Full record

Trial reportClinical cancer research : an official journal of the American Association for Cancer Research2021

Diagnostic Performance of

Michael J Morris, Steven P Rowe, Michael A Gorin, Lawrence Saperstein, Frédéric Pouliot, David Josephson, Jeffrey Y C Wong, Austin R Pantel, Steve Y Cho, Kenneth L Gage and 10 more

2 registry-linked trialsOpen access · bronzeAbstract readClinical Trial, Phase IIIMulticenter Study
In one paragraph

Trial report in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 221 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 6 pooled it
39.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05936658 phase3active not recruitingnot on this mapstarted 2023, after this paper: background citation

A Multi-center, Open-label, Single Arm Phase III Clinical Trial for the Diagnostic Efficacy Assessment and Safety Evaluation by [18F]Florastamin PET/CT Imaging Examination in Patients With Suspected Recurrent or Metastatic Prostate Cancer

TypeinterventionalSponsorFutureChemRan2023 to 2025Enrolled138ConditionsHigh Risk Prostate CarcinomaArms[F-18]Florastamin
NCT07635524 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Two Center Phase 2 Trial of 61Cu-noDAGa-PSMA I&T (61Cu-NU101) for Patients With Prostate Cancer

TypeinterventionalSponsorHoag Memorial Hospital PresbyterianRan2026 to 2028Enrolled34ConditionsProstate CancerArmsCu-NU101
3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 6 syntheses or guidelines pooled it, 358 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Utility of PSMA PET/CT in Staging and Restaging of Renal Cell Carcinoma: A Systematic Review and Metaanalysis.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Pooled it
  4. Effect ofFrontiers in medicine · 2024
    Pooled it
  5. Pooled it
  6. Guideline
  7. Radiographic Progression With and Without Prostate-Specific Antigen Rise in Patients With Advanced Prostate Cancer Treated With Enzalutamide.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2026
    Trial
  8. An intra-patient contemporaneous comparison ofEuropean journal of nuclear medicine and molecular imaging · 2026
    Trial
  9. Trial
  10. Imaging Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  11. Imaging Efficacy of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  12. Safety, Dosimetry, and Feasibility of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Trial
  13. Cancer imaging : the official publication of the International Cancer Imaging Society · 2025
    Trial
  14. Interreader and Intrareader Reproducibility ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Trial
  15. True-PositiveJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2024
    Trial
  16. Trial
  17. Diagnostic accuracy of fully hybrid [European journal of nuclear medicine and molecular imaging · 2024
    Trial
  18. AnCurrent radiopharmaceuticals · 2024
    Trial
  19. [European journal of nuclear medicine and molecular imaging · 2023
    Trial
  20. Radiology · 2022
    Trial

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 14 institutions in 2 countries.

Michael J Morris *Memorial Sloan Kettering Cancer Center, New York, New York. morrism@mskcc.org.ORCID 0000-0002-9454-0096
Steven P Rowe *The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Michael A GorinThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Lawrence SapersteinYale School of Medicine, New Haven, Connecticut.
Frédéric PouliotCHU de Quebec and Laval University, Quebec City, Canada.ORCID 0000-0002-6651-1079
David JosephsonTower Urology, Cedars Sinai Medical Center, Los Angeles, California.
Jeffrey Y C WongCity of Hope, Sierra Madre, California.
Austin R PantelHospital of the University of Pennsylvania, Philadelphia, Pennsylvania.
Steve Y ChoUniversity of Wisconsin-Madison, Madison, Wisconsin.ORCID 0000-0003-2724-7778
Kenneth L GageDiagnostic Imaging and Interventional Radiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.
Morand PiertRadiology, University of Michigan, Ann Arbor, Michigan.ORCID 0000-0002-3767-5648
Andrei IagaruStanford University, Stanford, California.ORCID 0000-0003-0839-5329
Janet H PollardUniversity of Iowa Hospital, Iowa City, Iowa.
Vivien WongProgenics Pharmaceuticals, Inc., New York, New York.
Jessica JensenProgenics Pharmaceuticals, Inc., New York, New York.
Tess LinProgenics Pharmaceuticals, Inc., New York, New York.
Nancy StamblerProgenics Pharmaceuticals, Inc., New York, New York.
Peter R CarrollUniversity of California San Francisco, San Francisco, California.
CONDOR Study Group
Progenics Pharmaceuticals (United States) · USJohns Hopkins University · USCedars-Sinai Medical Center · USHospital of the University of Pennsylvania · USMallinckrodt (United States) · USMemorial Sloan Kettering Cancer Center · USMoffitt Cancer Center · USSierra Engineering (United States) · USStanford University · USUniversité Laval · CAUniversity of California, San Francisco · USUniversity of Iowa Hospitals and Clinics · USUniversity of Michigan · USUniversity of Wisconsin–Madison · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
PURCHASE OF A SIEMENS NEXT GENERATION PET/CTS10OD025214 · OD · WASHINGTON UNIVERSITY · PI WOODARD, PAMELA K · 2018 to 2018
$2.0M
NCI NIH HHS P30 CA008748NIH HHS S10 OD025214
6 · The paper itself

Abstract

purposeCurrent FDA-approved imaging modalities are inadequate for localizing prostate cancer biochemical recurrence (BCR). EXPERIMENTAL

designMen with rising PSA ≥0.2 ng/mL after prostatectomy or ≥2 ng/mL above nadir after radiotherapy were eligible. The primary endpoint was correct localization rate (CLR), defined as positive predictive value with an additional requirement of anatomic lesion colocalization between

resultsA total of 208 men with a median baseline PSA of 0.8 ng/mL (range: 0.2-98.4 ng/mL) underwent

conclusionsPerformance of

Indexed as

AdultAgedAged, 80 and overHumansLysineMaleMiddle AgedNeoplasm Recurrence, LocalPositron Emission Tomography Computed TomographyProspective StudiesProstate-Specific AntigenProstatic NeoplasmsUrea2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acidLysineProstate-Specific AntigenUrea

Identifiers

PMID33622706
PMCPMC8382991
OpenAlexW3129520566

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.