ArticleUltrasound in medicine & biology2021
Transcranial Focused Ultrasound Enhances Sensory Discrimination Capability through Somatosensory Cortical Excitation.
Article in Ultrasound in medicine & biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 66 citations in OpenAlex.
- Neuromodulation effects of low-intensity transcranial focused ultrasound in human, a systematic review focusing on motor and sensory functions.Journal of neuroengineering and rehabilitation · 2025Pooled it
- The human amygdala in threat learning and extinction.Science advances · 2026Article
- Transcranial focused ultrasound induces source localizable cortical activation in resting state humans when applied concurrently with transcranial electric stimulation.Nature communications · 2026Article
- Neuromodulation and cognition in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Channel-specific differential effects of bacterial mechanosensitive channels for ultrasound neuromodulation in precision sonogenetics.Theranostics · 2026Article
- Neuromodulation with Ultrasound: Hypotheses on the Directionality of Effects and Community Resource.medRxiv : the preprint server for health sciences · 2025Article
- Transcranial Focused Ultrasound Modulates Feedforward and Feedback Cortico-Thalamo-Cortical Pathways by Selectively Activating Excitatory Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Comprehensive Review of Low-Intensity Focused Ultrasound Parameters and Applications in Neurologic and Psychiatric Disorders.Neuromodulation : journal of the International Neuromodulation Society · 2025Review
- Improving Targeting Specificity of Transcranial Focused Ultrasound in Subject Specific Head Models Using a Random Array Transducer: A k-Wave Simulation Study.IEEE access : practical innovations, open solutions · 2025Article
- Multi-visual pattern mining algorithm based on variational inference Gaussian mixture and pattern activation response map model.PloS one · 2025Article
- Dynamic changes in human brain connectivity following ultrasound neuromodulation.Scientific reports · 2024Article
- Transcranial Focused Ultrasound Neuromodulation in Psychiatry: Main Characteristics, Current Evidence, and Future Directions.Brain sciences · 2024Review
- Advanced rehabilitation in ischaemic stroke research.Stroke and vascular neurology · 2024Review
- Auditory confounds can drive online effects of transcranial ultrasonic stimulation in humans.eLife · 2024Article
- Transcranial focused ultrasound to V5 enhances human visual motion brain-computer interface by modulating feature-based attention.Nature communications · 2024Article
- A review of functional neuromodulation in humans using low-intensity transcranial focused ultrasound.Biomedical engineering letters · 2024Review
- Therapeutic ultrasound: an innovative approach for targeting neurological disorders affecting the basal ganglia.Frontiers in neuroanatomy · 2024Review
- Diagnostic ultrasound enhances, then reduces, exogenously induced brain activity of mice.Frontiers in human neuroscience · 2024Article
- Excitatory-inhibitory modulation of transcranial focus ultrasound stimulation on human motor cortex.CNS neuroscience & therapeutics · 2023Article
- Low-Intensity Focused Ultrasound Neuromodulation for Stroke Recovery: A Novel Deep Brain Stimulation Approach for Neurorehabilitation?IEEE open journal of engineering in medicine and biology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Low-intensity transcranial focused ultrasound (tFUS) has emerged as a non-invasive brain neuromodulation tool with high spatial specificity. Previous studies attributed tFUS-enhanced sensory performance to the ultrasound-induced inhibitory neural effects. However, to date there is no direct evidence validating the neural mechanism underlying ultrasound-mediated somatosensory enhancement. In this study, healthy human subjects (N = 9) were asked to perform tactile vibration frequency discrimination tasks while tFUS was directed onto the primary somatosensory cortex. During this task, we simultaneously recorded 64-channel electroencephalography (EEG) signals and investigated the brain responses at both EEG sensors and source domains by means of electrophysiological source imaging (ESI). The behavioral results indicated that the subjects' discrimination ability was improved by tFUS with an increased percentage of correct responses. EEG and ESI results revealed that tFUS neuromodulation was able to improve sensory discrimination capability through excitatory effects at the targeted sensory cortex.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.