Evidence map›Paper›PMID 33622471›Full record

ArticleEmerging infectious diseases2021

Transmission of Antimicrobial-Resistant Staphylococcus aureus Clonal Complex 9 between Pigs and Humans, United States.

Pranay R Randad, Jesper Larsen, Hülya Kaya, Nora Pisanic, Carly Ordak, Lance B Price, Maliha Aziz, Maya L Nadimpalli, Sarah Rhodes, Jill R Stewart and 8 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Microenvironment shapesiScience · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Animals : an open access journal from MDPI · 2022
    Article
  10. Antibiotic Resistance: From Pig to Meat.Antibiotics (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Pranay R Randad
Jesper Larsen
Hülya Kaya
Nora Pisanic
Carly Ordak
Lance B Price
Maliha Aziz
Maya L Nadimpalli
Sarah Rhodes
Jill R Stewart
Dave C Love
David Mohr
Meghan F Davis
Lloyd S Miller
Devon Hall
Karen C Carroll
Trish M Perl
Christopher D Heaney

Funding

Targeted Research Training CoreT42OH008428 · OH · JOHNS HOPKINS UNIVERSITY · PI RAMACHANDRAN, GURUMURTHY · 2005 to 2025
$31.1M
Antimicrobial resistant E. coli before and after California Senate bill 27 (ARES): a natural experimentR01AI130066 · NIAID · KAISER FOUNDATION RESEARCH INSTITUTE · PI TARTOF, SARA · 2017 to 2021
$3.8M
Arsenic and immune response to influenza vaccination in pregnant women and newbornsR01ES026973 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HEANEY, CHRISTOPHER D, LABRIQUE, ALAIN BERNARD · 2017 to 2021
$3.6M
IL-36 responses in Staphylococcus aureus driven skin inflammationR01AR073665 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2018 to 2022
$1.8M
STAT3-mediated immunity to Staphylococcus aureus in skinR01AR069502 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI ARCHER, NATHAN K. · 2016 to 2020
$1.8M
Rapid Emergence of Livestock-associated MRSA ST398: Host-adaptation & VirulenceR01AI101371 · NIAID · TRANSLATIONAL GENOMICS RESEARCH INST · PI PRICE, LANCE BRADLEY · 2013 to 2016
$1.6M
Effects of pest and pet animal microbiota on child microbiota and asthma: a one health studyK01OD019918 · OD · JOHNS HOPKINS UNIVERSITY · PI DAVIS, MEGHAN F. · 2016 to 2020
$621k
Multiplex oral fluid antibody assay for arbovirus diagnosis, surveillance and preventionR21AI139784 · NIAID · JOHNS HOPKINS UNIVERSITY · PI COLLINS, MATTHEW, HEANEY, CHRISTOPHER D · 2018 to 2019
$459k
Non-Invasive Zoonotic Pathogen Exposure & Outcome BiomarkersK01OH010193 · OH · JOHNS HOPKINS UNIVERSITY · PI HEANEY, CHRISTOPHER D · 2012 to 2014
$324k
Development of a point of care lateral flow diagnostic to test for acute and past hepatitis E (HEV) in salivaR43AI141265 · NIAID · NANOCOMPOSIX, INC. · PI BALDWIN, RICHARD KIMO, PISANIC, NORA · 2018 to 2018
$225k
ACL HHS T42OH008428NIAID NIH HHS R01 AI101371NIAID NIH HHS R01 AI130066NIAID NIH HHS R21 AI139784NIAID NIH HHS R43 AI141265NIAMS NIH HHS R01 AR069502NIAMS NIH HHS R01 AR073665NIEHS NIH HHS R01 ES026973NIH HHS K01 OD019918NIOSH CDC HHS K01 OH010193NIOSH CDC HHS T42 OH008428
6 · The paper itself

Abstract

Transmission of livestock-associated Staphylococcus aureus clonal complex 9 (LA-SA CC9) between pigs raised on industrial hog operations (IHOs) and humans in the United States is poorly understood. We analyzed whole-genome sequences from 32 international S. aureus CC9 isolates and 49 LA-SA CC9 isolates from IHO pigs and humans who work on or live near IHOs in 10 pig-producing counties in North Carolina, USA. Bioinformatic analysis of sequence data from the 81 isolates demonstrated 3 major LA-SA CC9 clades. North Carolina isolates all fell within a single clade (C3). High-resolution phylogenetic analysis of C3 revealed 2 subclades of intermingled IHO pig and human isolates differing by 0-34 single-nucleotide polymorphisms. Our findings suggest that LA-SA CC9 from pigs and humans share a common source and provide evidence of transmission of antimicrobial-resistant LA-SA CC9 between IHO pigs and humans who work on or live near IHOs in North Carolina.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnimal HusbandryAnimalsAnti-Bacterial AgentsHumansLivestockNorth CarolinaPhylogenyStaphylococcus aureusSwineUnited StatesAnti-Bacterial AgentsAMRantimicrobial resistancebacteriafood safetyindustrial hog operationsinfectious disease transmissionlivestock-associated diseasesMRSA and other staphylococcimultidrug-resistant bacteriaNorth CarolinapigsStaphylococcus aureusUnited Stateszoonoseszoonotic transmission

Identifiers

PMID33622471
PMCPMC7920674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.