Observational studyInfection control and hospital epidemiology2021
Rural-urban differences in antibiotic prescribing for uncomplicated urinary tract infection.
Observational study in Infection control and hospital epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Carbapenem-resistantbioRxiv : the preprint server for biology · 2026Article
- Evaluation of effectiveness of a regional remote antimicrobial stewardship program.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Prevalence and antimicrobial resistance ofFrontiers in microbiology · 2026Article
- The changing landscape of outpatient antibiotic prescriptions among advanced practice clinicians in the United States, 2011 and 2022.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2026Article
- Current Scientific Advances in Vaccines Against UTIs: Challenges and Prospects.Microorganisms · 2025Review
- An Analysis of Primary Healthcare Antibiotic Prescription Rates Within Castile and Leon (Spain): 2013-2023.Antibiotics (Basel, Switzerland) · 2025Article
- Antibiotic Use in Pediatrics: Perceptions and Practices of Romanian Physicians.Antibiotics (Basel, Switzerland) · 2025Article
- Co-Infection Dynamics ofInternational journal of molecular sciences · 2025Review
- Unnecessary Antibiotics in Older Female Patients with Recurrent Urinary Tract Infections.International urogynecology journal · 2025Article
- A Pilot Study on Understanding the Contextual Factors Impacting the Implementation of an Antibiotic Stewardship Program in a Single Health Center Serving Rural and Underserved Communities in the United States-A Mixed-Methods Approach.Antibiotics (Basel, Switzerland) · 2025Article
- Risk Factors for Empiric Treatment Failure in US Female Outpatients with Uncomplicated Urinary Tract Infection: an Observational Study.Journal of general internal medicine · 2025Observational
- Assessing community antibiotic usage and adherence as per standard treatment guidelines: A potential area to enhance awareness at community pharmacy settings.Exploratory research in clinical and social pharmacy · 2025Article
- Antibiotic Overprescription for "Urinary Tract Infections" Is Associated With Poor Diagnostic Stewardship and Low Adherence to Guidelines.Neurourology and urodynamics · 2025Article
- Outpatient antibiotic stewardship during the COVID-19 era: analysis of prescribing trends and guideline compliance.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2025Article
- Adherence to WHO/INRUD prescription indicators in public hospitals: evidence from the Ashanti Region, Ghana.Therapeutic advances in drug safety · 2025Article
- U.S. primary care physician perceptions on barriers to providing guideline-driven care for UTI and recurrent UTI: a qualitative study.BMC primary care · 2024Article
- Antibiotic Stewardship Interventions for Urinary Tract Infections in Outpatient Settings: A Narrative Review.Infectious disease clinics of North America · 2024Review
- Associations between Polycystic Ovary Syndrome (PCOS) and Antibiotic Use: Results from the UAEHFS.Antibiotics (Basel, Switzerland) · 2024Article
- Bacteremia From a Presumed Urinary Source in Hospitalized Adults With Asymptomatic Bacteriuria.JAMA network open · 2024Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine rural-urban differences in temporal trends and risk of inappropriate antibiotic use by agent and duration among women with uncomplicated urinary tract infection (UTI).
designObservational cohort study.
methodsUsing the IBM MarketScan Commercial Database (2010-2015), we identified US commercially insured women aged 18-44 years coded for uncomplicated UTI and prescribed an oral antibiotic agent. We classified antibiotic agents and durations as appropriate versus inappropriate based on clinical guidelines. Rural-urban status was defined by residence in a metropolitan statistical area. We used modified Poisson regression to determine the association between rural-urban status and inappropriate antibiotic receipt, accounting for patient- and provider-level characteristics. We used multivariable logistic regression to estimate trends in antibiotic use by rural-urban status.
resultsOf 670,450 women with uncomplicated UTI, a large proportion received antibiotic prescriptions for inappropriate agents (46.7%) or durations (76.1%). Compared to urban women, rural women were more likely to receive prescriptions with inappropriately long durations (adjusted risk ratio 1.10, 95% CI, 1.10-1.10), which was consistent across subgroups. From 2011 to 2015, there was slight decline in the quarterly proportion of patients who received inappropriate agents (48.5% to 43.7%) and durations (78.3% to 73.4%). Rural-urban differences varied over time by agent (duration outcome only), geographic region, and provider specialty.
conclusionsInappropriate antibiotic prescribing is quite common for the treatment of uncomplicated UTI. Rural women are more likely to receive inappropriately long antibiotic durations. Antimicrobial stewardship interventions are needed to improve outpatient UTI antibiotic prescribing and to reduce unnecessary exposure to antibiotics, particularly in rural settings.
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