ArticleBMC plant biology2021
Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees.
Article in BMC plant biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Archipelago architecture and evolution of paclitaxel biosynthesis revealed by the Pseudotaxus chienii haplotype-resolved genome.Nature communications · 2026Article
- Recent advances inFrontiers in plant science · 2026Review
- Analysis genome of Pseudotaxus chienii reveals insights into the origin and evolution of taxane biosynthesis.Nature communications · 2025Article
- Multi-combination comparative transcriptome analysis response to MeJA and identifies genes putatively involved in oridonin biosynthesis in Isodon rubescens.BMC plant biology · 2025Article
- Tissue-specific partitioning of flavonoids and phenolic acids coordinates bioactivities in Ormosia henryi Prain.BMC plant biology · 2025Article
- Article
- Regulatory microRNAs and phasiRNAs of paclitaxel biosynthesis inFrontiers in plant science · 2024Article
- Mass spectrometry imaging and single-cell transcriptional profiling reveal the tissue-specific regulation of bioactive ingredient biosynthesis in Taxus leaves.Plant communications · 2023Article
- Metabolomics reveals the response of hydroprimed maize to mitigate the impact of soil salinization.Frontiers in plant science · 2023Article
- Transcriptome analysis provides insights into light condition effect on paclitaxel biosynthesis in yew saplings.BMC plant biology · 2022Article
- Chemical compositions and biological activities of the oils from the genusTurkish journal of chemistry · 2022Review
- TcMYB29a, an ABA-Responsive R2R3-MYB Transcriptional Factor, Upregulates Taxol Biosynthesis inFrontiers in plant science · 2022Article
- Role of female-predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol inHorticulture research · 2022Article
- Recent Research Progress in Taxol Biosynthetic Pathway and Acylation Reactions Mediated byMolecules (Basel, Switzerland) · 2021Review
- Identification and in-silico characterization of taxadien-5α-ol-O-acetyltransferase (TDAT) gene in Corylus avellana L.PloS one · 2021Article
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8 authors.
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Abstract
backgroundTaxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown.
resultsHigh accumulation of 10-DAB, taxol, and 7-E-PTX suggested that P. chienii is a good taxol-yielding species for large-scale cultivation. By the omics approaches, a total of 3,387 metabolites and 61,146 unigenes were detected and annotated. Compared with a representative Taxus tree (Taxus yunnanensis), most of the differentially accumulated metabolites and differential expressed genes were assigned into 10 primary and secondary metabolism pathways. Comparative analyses revealed the variations in the precursors and intermediate products of taxol biosynthesis between P. chienii and T. yunnanensis. Taxusin-like metabolites highly accumulated in P. chienii, suggesting a wider value of P. chienii in pharmaceutical industry.
conclusionsIn our study, the occurrence of taxoids in P. chienii was determined. The differential expression of key genes involved in the taxol biosynthesis pathway is the major cause of the differential accumulation of taxoids. Moreover, identification of a number of differentially expressed transcription factors provided more candidate regulators of taxol biosynthesis. Our study may help to reveal the differences between Pseudotaxus and Taxus trees, and promote resource utilization of the endangered and rarely studied P. chienii.
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