ArticleJournal of the Royal Society, Interface2021
Fibril density reduction in keratoconic corneas.
Article in Journal of the Royal Society, Interface, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- The Matricellular Protein CCN1 Induces Corneal Stromal Cells Senescence and Inflammation to Trigger Extracellular Matrix Remodeling in Keratoconus.Investigative ophthalmology & visual science · 2026Article
- Staging of Keratoconus Indices Based on Localized Corneal Biomechanics Stress-Strain Index Map.Ophthalmology science · 2026Article
- Advancing subclinical keratoconus detection using polarization-sensitive optical coherence tomography and artificial intelligence.Biophotonics discovery · 2026Article
- Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas Using Motion Tracking Brillouin Microscopy.American journal of ophthalmology · 2025Article
- Evaluating corneal cross-linking using Stress-Strain Index maps: a finite element study.Journal of the Royal Society, Interface · 2025Article
- Application of the Brillouin Optical Scanning System in the Regional Corneal Biomechanical Evaluation of Keratoconus and Its Correlation with Corvis ST Parameters.Bioengineering (Basel, Switzerland) · 2025Article
- Review
- Biomechanics of keratoconus: Two numerical studies.PloS one · 2023Article
- Quantitative Assessment of Biomechanical Properties of the Human Keratoconus Cornea Using Acoustic Radiation Force Optical Coherence Elastography.Translational vision science & technology · 2022Article
- Article
- Spectral Transmission of the Human Corneal Layers.Journal of clinical medicine · 2021Article
- Stress-Strain Index Map: A New Way to Represent Corneal Material Stiffness.Frontiers in bioengineering and biotechnology · 2021Article
- Brillouin microscopy for focal biomechanical measurements in normal and keratoconic corneas: A narrative review.Survey of ophthalmologyReview
- Opto-biomechanical simulation of keratoconus development in emmetropic eyes.Journal of optometryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 4 countries.
Funding
Abstract
This study aims to estimate the reduction in collagen fibril density within the central 6 mm radius of keratoconic corneas through the processing of microstructure and videokeratography data. Collagen fibril distribution maps and topography maps were obtained for seven keratoconic and six healthy corneas, and topographic features were assessed to detect and calculate the area of the cone in each keratoconic eye. The reduction in collagen fibril density within the cone area was estimated with reference to the same region in the characteristic collagen fibril maps of healthy corneas. Together with minimum thickness and mean central corneal refractive power, the cone area was correlated with the reduction in the cone collagen fibrils. For the corneas considered, the mean area of keratoconic cones was 3.30 ± 1.90 mm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.