Evidence map›Paper›PMID 33622136›Full record

ArticleProceedings. Biological sciences2021

Koala methylomes reveal divergent and conserved DNA methylation signatures of X chromosome regulation.

Devika Singh, Dan Sun, Andrew G King, David E Alquezar-Planas, Rebecca N Johnson, David Alvarez-Ponce, Soojin V Yi

Open access · hybridAbstract read
In one paragraph

Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. A Thiopurine-like Mutagenic Process Defines TGCT Subtypes.bioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Imprinted X chromosome inactivation in marsupials: The paternal X arrives at the egg with a silent DNA methylation profile.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Review
  10. Article
  11. Article
  12. Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Devika SinghSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Dan SunSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Andrew G KingAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
David E Alquezar-PlanasAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
Rebecca N JohnsonAustralian Museum Research Institute, Australian Museum, Sydney, New South Wales, Australia.
David Alvarez-PonceDepartment of Biology, University of Nevada Reno, Reno, NV, USA.
Soojin V YiSchool of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA.
Georgia Institute of Technology · USAustralian Museum · AUSmithsonian Institution · USUniversity of Nevada, Reno · US

Funding

Single Cell Molecular ExpressionP30GM110767 · NIGMS · UNIVERSITY OF NEVADA RENO · PI SANDERS, KENTON M · 2014 to 2018
$5.4M
Human Specific Brain DNA Methylation and Neuropsychiatric DiseasesR01MH103517 · NIMH · GEORGIA INSTITUTE OF TECHNOLOGY · PI JORDAN, IRVING KING, PREUSS, TODD M · 2015 to 2019
$3.5M
A Computational Biology and Predictive Health Genomics Training Program at GTT32GM105490 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GIBSON, GREGORY C · 2014 to 2018
$901k
NIGMS NIH HHS P30 GM110767NIGMS NIH HHS T32 GM105490NIMH NIH HHS R01 MH103517
6 · The paper itself

Abstract

X chromosome inactivation (XCI) mediated by differential DNA methylation between sexes is an iconic example of epigenetic regulation. Although XCI is shared between eutherians and marsupials, the role of DNA methylation in marsupial XCI remains contested. Here, we examine genome-wide signatures of DNA methylation across fives tissues from a male and female koala (

Indexed as

PhascolarctidaeAnimalsDNA MethylationEpigenesis, GeneticEpigenomeFemaleMaleX ChromosomeDNA methylationkoalamarsupialRsxwhole-genome bisulfite sequencingX chromosome inactivation

Identifiers

PMID33622136
PMCPMC7934952
OpenAlexW3130111796

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.