ArticleProceedings. Biological sciences2021
Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice.
Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- From Single Cells to Silicon: Emerging Technologies Transforming Monoclonal Antibody Discovery.Antibodies (Basel, Switzerland) · 2026Review
- ePlatypus: an ecosystem for computational analysis of immunogenomics data.Bioinformatics (Oxford, England) · 2023Article
- Article
- Persistent virus-specific and clonally expanded antibody-secreting cells respond to induced self-antigen in the CNS.Acta neuropathologica · 2023Article
- Comprehensive multi-omics single-cell data integration reveals greater heterogeneity in the human immune system.iScience · 2022Article
- Single-cell immune repertoire sequencing of B and T cells in murine models of infection and autoimmunity.Genes and immunity · 2022Article
- Echidna: integrated simulations of single-cell immune receptor repertoires and transcriptomes.Bioinformatics advances · 2022Article
- Clonally Expanded Virus-Specific CD8 T Cells Acquire Diverse Transcriptional Phenotypes During Acute, Chronic, and Latent Infections.Frontiers in immunology · 2022Article
- Single-cell immune repertoire and transcriptome sequencing reveals that clonally expanded and transcriptionally distinct lymphocytes populate the aged central nervous system in mice.Proceedings. Biological sciences · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroinflammation plays a crucial role during ageing and various neurological conditions, including Alzheimer's disease, multiple sclerosis and infection. Technical limitations, however, have prevented an integrative analysis of how lymphocyte immune receptor repertoires and their accompanying transcriptional states change with age in the central nervous system. Here, we leveraged single-cell sequencing to simultaneously profile B cell receptor and T cell receptor repertoires and accompanying gene expression profiles in young and old mouse brains. We observed the presence of clonally expanded B and T cells in the central nervous system of aged male mice. Furthermore, many of these B cells were of the IgM and IgD isotypes, and had low levels of somatic hypermutation. Integrating gene expression information additionally revealed distinct transcriptional profiles of these clonally expanded lymphocytes. Our findings implicate that clonally related T and B cells in the CNS of elderly mice may contribute to neuroinflammation accompanying homeostatic ageing.
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