ArticleProceedings. Biological sciences2021
Positive selection and gene duplications in tumour suppressor genes reveal clues about how cetaceans resist cancer.
Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 57 citations in OpenAlex.
- Advancing Marine Mammal Conservation Through Omics Tools and Integration of Indigenous Ecological Knowledge.Molecular ecology · 2026Review
- From few to many: How non-model organisms' genomics broadened our understanding of molecular evolution.Genetics and molecular biology · 2026Article
- First insights into the miRNA landscape of Tursiops truncatus milk reveal shared dominant microRNA families with terrestrial mammals.PloS one · 2026Article
- Shrinking to bird size with dinosaur-level cancer defences: Evolution of cancer suppression over macroevolutionary time.PLoS computational biology · 2025Article
- DNA repair and anti-cancer mechanisms in the long-lived bowhead whale.bioRxiv : the preprint server for biology · 2024Article
- Thermal stress, p53 structures and learning from elephants.Cell death discovery · 2024Review
- Evolution of ion channels in cetaceans: a natural experiment in the tree of life.Scientific reports · 2024Article
- Article
- Arginines of the CGN codon family are Achilles' heels of cancer genes.Scientific reports · 2024Article
- Pathogenic variants in human DNA damage repair genes mostly arose in recent human history.BMC cancer · 2024Article
- A High-Quality Blue Whale Genome, Segmental Duplications, and Historical Demography.Molecular biology and evolution · 2024Article
- Duplications of Human Longevity-Associated Genes Across Placental Mammals.Genome biology and evolution · 2023Article
- Using epigenetic clocks to investigate changes in the age structure of critically endangered Māui dolphins.Ecology and evolution · 2023Article
- Long-Read Sequencing Reveals Rapid Evolution of Immunity- and Cancer-Related Genes in Bats.Genome biology and evolution · 2023Article
- Review
- An insight into cancer palaeobiology: does the Mesozoic neoplasm support tissue organization field theory of tumorigenesis?BMC ecology and evolution · 2022Article
- Comparative study of the evolution of cancer gene duplications across fish.Evolutionary applications · 2022Article
- Cancer suppression and the evolution of multiple retrogene copies of TP53 in elephants: A re-evaluation.Evolutionary applications · 2022Article
- Distinguishing Evolutionary Conservation from Derivedness.Life (Basel, Switzerland) · 2022Review
- Increased risk of cancer in dogs and humans: a consequence of recent extension of lifespan beyond evolutionarily-determined limitations?Aging and cancer · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
Abstract
Cetaceans are the longest-living species of mammals and the largest in the history of the planet. They have developed mechanisms against diseases such cancer, although the underlying molecular bases of these remain unknown. The goal of this study was to investigate the role of natural selection in the evolution of 1077 tumour suppressor genes (TSGs) in cetaceans. We used a comparative genomic approach to analyse two sources of molecular variation in the form of
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Registered trials
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