Evidence map›Paper›PMID 33622073›Full record

Observational studyJournal of geriatric psychiatry and neurology2022

Bidirectional Correlations Between Dopaminergic Function and Motivation in Parkinson's Disease.

Jared T Hinkle, Kelly A Mills, Kate Perepezko, Gregory M Pontone

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of geriatric psychiatry and neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jared T HinkleMedical Scientist Training Program, 1500Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6770-3067
Kelly A MillsDepartment of Neurology, 1500Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kate PerepezkoDepartment of Mental Health, 25802Johns Hopkins Bloomberg School of Public Health, Dept. of Mental Health, Baltimore, MD, USA.
Gregory M PontoneDepartment of Psychiatry, 1500Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Johns Hopkins University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Anxiety in Parkinson's: Use of quantitative methods to guide rational treatmentK23AG044441 · NIA · JOHNS HOPKINS UNIVERSITY · PI PONTONE, GREGORY MICHAEL · 2014 to 2018
$1.0M
Molecular Imaging of the Nicotinic Cholinergic Receptor in Parkinson's disease (PD): Implication of for understanding the neurobiology of cognitive impairmentK23NS101096 · NINDS · JOHNS HOPKINS UNIVERSITY · PI MILLS, KELLY ALEXANDER · 2017 to 2021
$1000k
Astrocyte NLRP3 inflammasome activation in Parkinson's diseaseF30AG067643 · NIA · JOHNS HOPKINS UNIVERSITY · PI HINKLE, JARED · 2020 to 2022
$153k
NIA NIH HHS F30 AG067643NIA NIH HHS K23 AG044441NIGMS NIH HHS T32 GM007309NIGMS NIH HHS T32 GM136577NINDS NIH HHS K23 NS101096
6 · The paper itself

Abstract

objectiveTo test the hypothesis that striatal dopamine function influences motivational alterations in Parkinson disease (PD), we compared vesicular monoamine transporter 2 (VMAT2) and dopamine transporter (DaT) imaging data in PD patients with impulse control disorders (ICDs), apathy, or neither.

methodsWe extracted striatal binding ratios (SBR) from VMAT2 PET imaging (

resultsAmong 23 participants (mean age 62.7 years, mean disease duration 1.8 years) with VMAT2 imaging data, 5 had apathy, 5 had an ICD, and 13 had neither. ANOVA indicated strong groupwise differences in VMAT2 binding in right anterior putamen [F(2,20) = 16.2, p < 0.0001), right posterior putamen [F(2,20) = 16.9, p < 0.0001), and right caudate [F(2,20) = 6.8, p = 0.006)]. Post-hoc tests and repeated-measures analysis with LME regression also supported right striatal VMAT2 elevation in the ICD group and reduction in the apathy group relative to the group with neither ICD nor apathy. DaT did not exhibit similar correlations, but normalizing VMAT2 with DaT SBR strengthened bidirectional correlations with ICD (high VMAT2/DaT) and apathy (low VMAT2/DaT) in all striatal regions bilaterally.

conclusionsOur findings constitute preliminary evidence that striatal presynaptic dopaminergic function helps describe the neurobiological basis of motivational dysregulation in PD, from high in ICDs to low in apathy.

Indexed as

Parkinson DiseaseCorpus StriatumDopamineHumansMotivationPositron-Emission TomographyDopamineapathybiomarkersdopaminedopamine transportergeriatric psychiatryimpulse control disordersmotivationmovement disorderneuropsychological testingParkinson’s diseasePPMIVMAT2

Identifiers

PMID33622073
PMCPMC8382801
OpenAlexW3131084139

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.