Observational studyOsteoarthritis and cartilage2021
The Central Aspects of Pain in the Knee (CAP-Knee) questionnaire; a mixed-methods study of a self-report instrument for assessing central mechanisms in people with knee pain.
Observational study in Osteoarthritis and cartilage, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Translation, cross-cultural adaptation and measurement properties of the Brazilian Portuguese version of the central aspects of pain in the knee in individuals with knee osteoarthritis.Brazilian journal of physical therapy · 2026Article
- Meditations on Methodological Issues in Clinical Investigations of "Central Sensitization" (Jonah XII).Journal of clinical medicine · 2026Article
- Observational
- Patient and public involvement in musculoskeletal pain research: using mutual learning to improve research quality.Therapeutic advances in musculoskeletal disease · 2026Review
- Cross-Cultural Adaptation and Validation for Central Aspects of Pain in the Knee Questionnaire: Based on Chinese Patients Undergoing Total Knee Arthroplasty for Knee Osteoarthritis.Journal of pain research · 2026Article
- Article
- Validity and contributions to pain from the central aspects of pain questionnaire in rheumatoid arthritis.Pain reports · 2025Article
- Central aspects of pain associated with physical activity: results from the Investigating Musculoskeletal Health and Wellbeing cohort.Pain reports · 2025Article
- The importance of central sensitization for clinical trials of disease modifying osteoarthritis drugs (DMOADs).Osteoarthritis imaging · 2025Article
- Cross-cultural adaption, validity, and reliability of the Japanese version of the Central Aspects of Pain in the Knee (CAP-Knee-J) questionnaire in patients with knee pain: a validation study.BMC musculoskeletal disorders · 2024Article
- Limited content overlap between commonly used self-report instruments for central (pain) sensitization in rheumatology.Rheumatology advances in practice · 2024Article
- Article
- Associations of Muscle Strength with Central Aspects of Pain: Data from the Knee Pain and Related Health in the Community (KPIC) Cohort.Journal of personalized medicine · 2023Article
- Article
- Do the instruments used to assess fibromyalgia symptoms according to American College of Rheumatology criteria generate similar scores in other chronic musculoskeletal pain?BMC musculoskeletal disorders · 2023Article
- Patellofemoral Pain, Q-Angle, and Performance in Female Chinese Collegiate Soccer Players.Medicina (Kaunas, Lithuania) · 2023Article
- Reproducible microbiome composition signatures of anxiety and depressive symptoms.Computational and structural biotechnology journal · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesPain is the prevailing symptom of knee osteoarthritis. Central sensitisation creates discordance between pain and joint pathology. We previously reported a Central Pain Mechanisms trait derived from eight discrete characteristics: Neuropathic-like pain, Fatigue, Cognitive-impact, Catastrophising, Anxiety, Sleep disturbance, Depression, and Pain distribution. We here validate and show that an 8-item questionnaire, Central Aspects of Pain in the Knee (CAP-Knee) is associated both with sensory- and affective- components of knee pain severity.
methodsParticipants with knee pain were recruited from the Investigating Musculoskeletal Health and Wellbeing study in the East Midlands, UK. CAP-Knee items were refined following cognitive interviews. Psychometric properties were assessed in 250 participants using Rasch-, and factor-analysis, and Cronbach's alpha. Intra-class correlation coefficients tested repeatability. Associations between CAP-Knee and McGill Pain questionnaire pain severity scores were assessed using linear regression.
resultsCAP-Knee targeted the knee pain sample well. Cognitive interviews indicated that participants interpreted CAP-Knee items in diverse ways, which aligned to their intended meanings. Fit to the Rasch model was optimised by rescoring each item, producing a summated score from 0 to 16. Internal consistency was acceptable (Cronbach's alpha = 0.74) and test-retest reliability was excellent (ICC
conclusionCAP-Knee is a simple and valid self-report questionnaire, which measures a single 'Central Mechanisms' trait, and may help identify and target centrally-acting treatments aiming to reduce the burden of knee pain.
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