ArticleDevelopmental cell2021
A multiscale analysis of early flower development in Arabidopsis provides an integrated view of molecular regulation and growth control.
Article in Developmental cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- Article
- CRISPR/dCas9-targeted H3K27me3 demethylation at theiScience · 2025Article
- CUC/auxin patterning of decanalised petal number inQuantitative plant biology · 2025Article
- Altered interactions between cis-regulatory elements partially resolve BLADE-ON-PETIOLE genetic redundancy in Capsella rubella.The Plant cell · 2024Article
- What Is a Plant Cell Type in the Age of Single-Cell Biology? It's Complicated.Annual review of cell and developmental biology · 2024Review
- Water fluxes pattern growth and identity in shoot meristems.Nature communications · 2024Article
- Reflections on the ABC model of flower development.The Plant cell · 2024Review
- GRAS transcription factor PINNATE-LIKE PENTAFOLIATA2 controls compound leaf morphogenesis in Medicago truncatula.The Plant cell · 2024Article
- The dynamics and biophysics of shape formation: Common themes in plant and animal morphogenesis.Developmental cell · 2023Review
- A new negative link in flower development: Repression of ABC genes by Z factors-ZP1/ZFP8.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Old school, new rules: floral meristem development revealed by 3D gene expression atlases and high-resolution transcription factor-chromatin dynamics.Frontiers in plant science · 2023Review
- A Hands-On Guide to Generate Spatial Gene Expression Profiles by Integrating scRNA-seq and 3D-Reconstructed Microscope-Based Plant Structures.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The annotation and analysis of complex 3D plant organs using 3DCoordX.Plant physiology · 2022Article
- A 3D gene expression atlas of the floral meristem based on spatial reconstruction of single nucleus RNA sequencing data.Nature communications · 2022Article
- Benchmarking of deep learning algorithms for 3D instance segmentation of confocal image datasets.PLoS computational biology · 2022Review
- A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state.Cell research · 2022Article
- High-Throughput 3D Phenotyping of Plant Shoot Apical Meristems From Tissue-Resolution Data.Frontiers in plant science · 2022Article
- Stable establishment of organ polarity occurs several plastochrons before primordium outgrowth in Arabidopsis.Development (Cambridge, England) · 2021Article
- Cell identity specification in plants: lessons from flower development.Journal of experimental botany · 2021Review
- Article
Corrections and comments
- Commented on by
Authors and funding
18 authors.
Funding
Abstract
We have analyzed the link between the gene regulation and growth during the early stages of flower development in Arabidopsis. Starting from time-lapse images, we generated a 4D atlas of early flower development, including cell lineage, cellular growth rates, and the expression patterns of regulatory genes. This information was introduced in MorphoNet, a web-based platform. Using computational models, we found that the literature-based molecular network only explained a minority of the gene expression patterns. This was substantially improved by adding regulatory hypotheses for individual genes. Correlating growth with the combinatorial expression of multiple regulators led to a set of hypotheses for the action of individual genes in morphogenesis. This identified the central factor LEAFY as a potential regulator of heterogeneous growth, which was supported by quantifying growth patterns in a leafy mutant. By providing an integrated view, this atlas should represent a fundamental step toward mechanistic models of flower development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.