Evidence map›Paper›PMID 33621442›Full record

Trial reportPediatric pulmonology2021

Measures of ventilation heterogeneity mapped with hyperpolarized helium-3 MRI demonstrate a T2-high phenotype in asthma.

W Gerald Teague, Jaime Mata, Kun Qing, Nicholas J Tustison, John P Mugler, Craig H Meyer, Eduard E de Lange, Yun M Shim, Kristin Wavell, Talissa A Altes

Registry-linked trialOpen access · greenAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric pulmonology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02577497 (Effect of Extra- Fine Versus Coarse-Particle Inhaled Corticosteroids), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02577497 phase4completednot on this map

Effect of Extra- Fine Versus Coarse-Particle Inhaled Corticosteroids (ICS) on Ventilation Heterogeneity in Children With Poorly Controlled Asthma

TypeinterventionalSponsorUniversity of VirginiaRan2016 to 2018Enrolled31ConditionsAsthmaArmsbeclomethasone, fluticasone
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

W Gerald TeagueDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.ORCID 0000-0002-5596-606X
Jaime MataDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Kun QingDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Nicholas J TustisonDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
John P MuglerDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Craig H MeyerDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Eduard E de LangeDepartment of Radiology and Medical Imaging, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Yun M ShimDivision of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, Vorginia, USA.
Kristin WavellDepartment of Pediatrics, Child Health Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA.
Talissa A AltesDepartment of Radiology, University of Missouri School of Medicine, Columbia, Missouri, USA.
University of Virginia · USUniversity of Missouri · US

Funding

Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
Hyperpolarized Xenon-129 MRI: a new multi-dimensional biomarker to determine pulmonary physiologic responses to COPD therapeuticsR01HL132177 · NHLBI · UNIVERSITY OF VIRGINIA · PI QING, KUN, SHIM, YUN MICHAEL · 2017 to 2021
$3.9M
ITK-Lung: A Software Framework for Lung Image Processing and AnalysisR01HL133889 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C · 2017 to 2020
$2.3M
Motion-Robust Methods for Rapid Pediatric MRI without SedationR21EB022309 · NIBIB · UNIVERSITY OF VIRGINIA · PI MEYER, CRAIG H · 2016 to 2018
$539k
Lung rhinovirus (RV) infection identifies pre-school children with type 2 inflammation at risk for the development of asthmaR21AI151496 · NIAID · UNIVERSITY OF VIRGINIA · PI BORISH, LARRY C, TEAGUE, WILLIAM GERALD · 2020 to 2021
$444k
NHLBI NIH HHS R01 HL132177NHLBI NIH HHS R01 HL133889NHLBI NIH HHS U10 HL109250NIAID NIH HHS R21 AI151496NIBIB NIH HHS R21 EB022309
6 · The paper itself

Abstract

backgroundHyperpolarized gas with helium (HHe-3) MR (magnetic resonance) is a noninvasive imaging method which maps and quantifies regions of ventilation heterogeneity (VH) in the lung. VH is an important feature of asthma, but little is known as to how VH informs patient phenotypes. PURPOSE: To determine if VH indicators quantified by HHe-3 MR imaging (MRI) predict phenotypic characteristics and map to regions of inflammation in children with problematic wheeze or asthma.

methodsSixty children with poorly-controlled wheeze or asthma underwent HHe-3 MRI, including 22 with bronchoalveolar lavage (BAL). The HHe-3 signal intensity defined four ventilation compartments. The non-ventilated and hypoventilated compartments divided by the total lung volume defined a VH index (VHI %).

resultsChildren with VHI % in the upper quartile had significantly greater airflow limitation, bronchodilator responsiveness, blood eosinophils, expired nitric oxide (FeNO), and BAL eosinophilic or neutrophilic granulocyte patterns compared to children with VHI % in the lower quartile. Lavage return from hypoventilated bronchial segments had greater eosinophil % than from ventilated segments.

conclusionIn children with asthma, greater VHI % as measured by HHe-3 MRI identifies a severe phenotype with higher type 2 inflammatory markers, and maps to regions of lung eosinophilia. Listed on ClinicalTrials. gov (NCT02577497).

Indexed as

AsthmaHeliumHumansIsotopesLungMagnetic Resonance ImagingPhenotypeHeliumHelium-3Isotopeshelium-3 lung MRIhyperpolarized lung MRImaldistribution of ventilationsevere asthmaventilation heterogeneity

Identifiers

PMID33621442
PMCPMC8137549
OpenAlexW3129555040

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.