ArticleDepression and anxiety2021
Resting state functional connectivity correlates of rumination and worry in internalizing psychopathologies.
Article in Depression and anxiety, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Default Mode Network Modulation by Psychedelics: A Systematic Review.The international journal of neuropsychopharmacology · 2023Pooled it
- Air pollution, depressive and anxiety disorders, and brain effects: A systematic review.Neurotoxicology · 2022Pooled it
- Meta-analytic evidence that mindfulness training alters resting state default mode network connectivity.Scientific reports · 2022Pooled it
- Change in Resting-State Functional Connectivity Following Working Memory Training in Individuals With Repetitive Negative Thinking.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Trial
- Functional activity and connectivity signatures of ketamine and lamotrigine during negative emotional processing: a double-blind randomized controlled fMRI study.Translational psychiatry · 2024Trial
- Neural predictors of treatment outcome through emotion regulation in internalizing disorders: a narrative review.Translational psychiatry · 2026Review
- Emotional modulation of inhibitory control in rumination from empirical and computational perspectives.Cognitive, affective & behavioral neuroscience · 2026Article
- Latent patterns of rumination and hopelessness on self-harm behaviors in adolescence.Child and adolescent psychiatry and mental health · 2026Article
- The Desegregation of Neural Networks During Worry Induction in Late Life: An Effective Connectivity Analysis.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- A Neural Signature of the Bias Toward Self-Focus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Difficult-to-Treat Anxiety: A Neurocomputational Framework.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Review
- Neural correlates of rumination in remitted depressive episodes: Brain network connectivity and topology analyses.World journal of psychiatry · 2025Article
- Functional connectivity characteristics of epilepsy with anxiety: A resting-state functional near-infrared spectroscopy study.Medicine · 2025Observational
- Identifying Features of Resilience to Childhood Maltreatment in Resting-State Connectivity Data From Adults With and Without a History of Mood Disorder.Biological psychiatry global open science · 2025Article
- Resting state connectivity patterns associated with trait anxiety in adolescence.Scientific reports · 2025Article
- The Specificity of Metacognition Questionnaire-30 Subdimensions: Findings From Connectome-Based Predictive Modeling.Depression and anxiety · 2025Article
- Deficient salience and default mode functional integration in high worry-proneness subject: a connectome-wide association study.Brain imaging and behavior · 2024Article
- Unveiling Frequency-Specific Microstate Correlates of Anxiety and Depression Symptoms.Brain topography · 2024Article
- Translation of monosynaptic circuits underlying amygdala fMRI neurofeedback training.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- Specific Association of Worry With Amyloid-β But Not Tau in Cognitively Unimpaired Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundRumination and worry are repetitive negative thinking (RNT) tendencies that contribute to the development and maintenance of internalizing psychopathologies. Accruing data suggest rumination and worry represent overlapping and unique transdiagnostic cognitive processes. Yet, prior neuroimaging research has mostly focused on rumination in depression, which points to involvement of resting-state brain activity in default mode, executive, salience, and/or affective networks.
methodsThe current study examined relations between brain activity during rest and RNT in a transdiagnostic sample. Resting-state fMRI data was analyzed in 80 unmedicated patients with internalizing conditions. Regression analysis, controlling for anxiety and depression symptoms, was performed with seed regions implicated in default mode, executive, salience, and affective networks. Rumination and worry were assessed with standard self-report measures.
resultsWhole-brain regression results showed more rumination and worry jointly corresponded with greater positive resting-state functional connectivity (rsFC) between the amygdala and prefrontal regions (i.e., middle frontal gyrus, inferior frontal gyrus). Conversely, more worry (controlling for rumination) corresponded with greater negative rsFC between amygdala and precuneus. No significant results were observed for rumination alone (controlling for worry).
conclusionsFindings indicate the affective network plays a role in RNT, and distinct patterns of connectivity between amygdala and regions implicated in the executive and default mode networks were observed across patients with internalizing conditions. Results suggest different mechanisms contribute to RNT as a unitary construct and worry as a unique construct.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.