ArticleThe New phytologist2021
A gene-for-gene interaction involving a 'late' effector contributes to quantitative resistance to the stem canker disease in Brassica napus.
Article in The New phytologist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 33 citations in OpenAlex.
- Experimental dissection of phenotypic variation for quantitative disease resistance in canola (Brassica napus) - Leptosphaeria maculans interactions.Pest management science · 2026Article
- Segregating BCMolecular breeding : new strategies in plant improvement · 2026Article
- Parallel adaptation and admixture drive the evolution of virulence in the grapevine downy mildew pathogen.PLoS pathogens · 2026Article
- Conserved 'Late' Effector Genes From Leptosphaeria maculans Inducing Gene-For-Gene Quantitative Resistance in Brassica napus Semi-Winter Genotypes.Molecular plant pathology · 2026Article
- From Recognition to Response: Resistance-Effector Gene Interactions in thePlants (Basel, Switzerland) · 2025Review
- To be or not to be a nonhost species: A case study of the Leptosphaeria maculans and Brassica carinata interaction.Environmental microbiology reports · 2024Article
- Breeding and management of major resistance genes to stem canker/blackleg in Brassica crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Review
- Quantitative pathogenicity and host adaptation in a fungal plant pathogen revealed by whole-genome sequencing.Nature communications · 2024Article
- The neighbouring genes AvrLm10A and AvrLm10B are part of a large multigene family of cooperating effector genes conserved in Dothideomycetes and Sordariomycetes.Molecular plant pathology · 2023Article
- Novel gene loci associated with susceptibility or cryptic quantitative resistance to Pyrenopeziza brassicae in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Genome-wide association studies reveal novel loci for resistance to groundnut rosette disease in the African core groundnut collection.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- Identification of candidate genes forFrontiers in plant science · 2023Article
- Quantitative and qualitative plant-pathogen interactions call upon similar pathogenicity genes with a spectrum of effects.Frontiers in plant science · 2023Article
- "Late" effectors fromPlant direct · 2022Article
- Independent breakdown events of the Brassica napus Rlm7 resistance gene including via the off-target impact of a dual-specificity avirulence interaction.Molecular plant pathology · 2022Article
- Harnessing genetic resistance to rusts in wheat and integrated rust management methods to develop more durable resistant cultivars.Frontiers in plant science · 2022Review
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10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The control of stem canker disease of Brassica napus (rapeseed), caused by the fungus Leptosphaeria maculans is based largely on plant genetic resistance: single-gene specific resistance (Rlm genes) or quantitative, polygenic, adult-stage resistance. Our working hypothesis was that quantitative resistance partly obeys the gene-for-gene model, with resistance genes 'recognizing' fungal effectors expressed during late systemic colonization. Five LmSTEE (stem-expressed effector) genes were selected and placed under the control of the AvrLm4-7 promoter, an effector gene highly expressed at the cotyledon stage of infection, for miniaturized cotyledon inoculation test screening of a gene pool of 204 rapeseed genotypes. We identified a rapeseed genotype, 'Yudal', expressing hypersensitive response to LmSTEE98. The LmSTEE98-RlmSTEE98 interaction was further validated by inactivation of the LmSTEE98 gene with a CRISPR-Cas9 approach. Isolates with mutated versions of LmSTEE98 induced more severe stem symptoms than the wild-type isolate in 'Yudal'. This single-gene resistance was mapped in a 0.6 cM interval of the 'Darmor_bzh' × 'Yudal' genetic map. One typical gene-for-gene interaction contributes partly to quantitative resistance when L. maculans colonizes the stems of rapeseed. With numerous other effectors specific to stem colonization, our study provides a new route for resistance gene discovery, elucidation of quantitative resistance mechanisms and selection for durable resistance.
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