Evidence map›Paper›PMID 33621148›Full record

ArticleOcular immunology and inflammation2021

Contemporaneous Risk Factors for Visual Acuity in Non-Infectious Uveitis.

Maxwell Pistilli, Sapna S Gangaputra, Siddharth S Pujari, Douglas A Jabs, Grace A Levy-Clarke, Robert B Nussenblatt, James T Rosenbaum, H Nida Sen, Eric B Suhler, Jennifer E Thorne and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Ocular immunology and inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Risk of Cataract in Intermediate Uveitis.American journal of ophthalmology · 2021
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 8 institutions in 2 countries.

Maxwell Pistilliand the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group** Department of Ophthalmology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-4266-4150
Sapna S GangaputraDepartment of Ophthalmology and Vision Sciences, Vanderbilt Eye Institute, Nashville, Tennessee, USA.
Siddharth S PujariOm Eye Care Hospital, Belgaum, India.
Douglas A JabsDepartment of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Grace A Levy-ClarkeLaboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA.
Robert B NussenblattLaboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA.
James T RosenbaumDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
H Nida SenLaboratory of Immunology, National Eye Institute, Bethesda, Maryland, USA.
Eric B SuhlerDepartment of Ophthalmology, Oregon Health and Science University, Portland, Oregon, USA.
Jennifer E ThorneDepartment of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA.
Nirali P Bhattand the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group** Department of Ophthalmology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
C Stephen FosterMassachusetts Eye Research and Surgery Institution, Cambridge, Massachusetts, USA.
Hosne BegumDepartment of Ophthalmology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Tonetta D Fitzgeraldand the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group** Department of Ophthalmology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Kurt A Dregerand the Systemic Immunosuppressive Therapy for Eye Diseases (SITE) Research Group** Department of Ophthalmology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
John H KempenDepartment of Ophthalmology, Harvard Medical School, Boston, Massachusetts, USA.
Johns Hopkins University · USNational Eye Institute · USUniversity of Pennsylvania · USOregon Health & Science University · USHarvard University · USMassachusetts Eye and Ear Infirmary · USVanderbilt Health · USVasan Eye Care Hospital · IN

Funding

Studies of Ocular inflammation: Translational ResearchZIAEY000556 · NEI · NATIONAL EYE INSTITUTE · PI CASPI, RACHEL R. · 2017 to 2025
$11.3M
Complications of Immunosupression for Eye DiseasesR56EY014943 · NEI · UNIVERSITY OF PENNSYLVANIA · PI KEMPEN, JOHN H · 2009 to 2009
$159k
NEI NIH HHS R56 EY014943
6 · The paper itself

Abstract

introductionWe evaluated the associations of clinical and demographic characteristics with visual acuity (VA) with over 5 years in a subspecialty noninfectious uveitis population.

methodsRetrospective data from 5,530 noninfectious uveitis patients were abstracted by expert reviewers, and contemporaneous associations of VA with demographic and clinical factors were modeled.

resultsPatients were a median of 41 years old, 65% female, and 73% white. Eyes diagnosed ≥5 years prior to cohort entry had worse VA (-1.2 lines) than those diagnosed <6 months prior, and eyes with cataract surgery performed prior to entry had worse VA (-5.9 lines) than those performed during follow-up. Vitreous haze (-4.2 lines for 3+ vs quiet), hypotony (-2.5 lines for ≤5 mm Hg vs 6-23 mm Hg), and CNV (-1.8 lines) all were strongly associated with reduced VA.

conclusionFactors associated with reduced VA included well-known structural complications, and lack of subspecialty care during cataract surgery.

Indexed as

AdolescentAdultAgedCataract ExtractionFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsUveitisVision DisordersVisual AcuityYoung Adultrisk FactorsuveitisVisual Acuity

Identifiers

PMID33621148
OpenAlexW3132339705

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.