Evidence map›Paper›PMID 33621083›Full record

ArticleJournal of natural products2021

Biosynthetic Interrogation of Soil Metagenomes Reveals Metamarin, an Uncommon Cyclomarin Congener with Activity against

Lei Li, Logan W MacIntyre, Thahmina Ali, Riccardo Russo, Bimal Koirala, Yozen Hernandez, Sean F Brady

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lei LiLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.ORCID 0000-0003-2814-077X
Logan W MacIntyreLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.
Thahmina AliLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.
Riccardo RussoRutgers, The State University of New Jersey, International Center for Public Health, 225 Warren Street, Newark, New Jersey 07103, United States.
Bimal KoiralaLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.
Yozen HernandezLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.ORCID 0000-0003-3349-8856
Sean F BradyLaboratory of Genetically Encoded Small Molecules, The Rockefeller University, 1230 York Avenue, New York, New York 10065, United States.
Rockefeller University · USRutgers, The State University of New Jersey · US

Funding

Discovery of Antibiotics from Soil Microbiomes Using MetagenomicsR35GM122559 · NIGMS · ROCKEFELLER UNIVERSITY · PI SEAN F BRADY · 2017 to 2026
$4.7M
NIGMS NIH HHS R35 GM122559
6 · The paper itself

Abstract

Tuberculosis (TB) remains one of the deadliest infectious diseases. Unfortunately, the development of antibiotic resistance threatens our current therapeutic arsenal, which has necessitated the discovery and development of novel antibiotics against drug-resistant

Indexed as

MetagenomeSoil MicrobiologyAnimalsAntitubercular AgentsBacterial ProteinsCell LineHeat-Shock ProteinsMacrophagesMiceMicrobial Sensitivity TestsMolecular StructureMycobacterium tuberculosisOligopeptidesAntitubercular AgentsBacterial ProteinsClpC1 protein, Mycobacterium tuberculosiscyclomarin AHeat-Shock ProteinsOligopeptidesrufomycin

Identifiers

PMID33621083
PMCPMC8068612
OpenAlexW3133343543

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.