ArticleAddiction (Abingdon, England)2021
Genetic architecture of four smoking behaviors using partitioned SNP heritability.
Article in Addiction (Abingdon, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Loci on chromosome 20 interact with rs16969968 to influence cigarettes per day in European ancestry individuals.Drug and alcohol dependence · 2024Pooled it
- Polygenic scores for tobacco use provide insights into systemic health risks in a diverse EHR-linked biobank in Los Angeles.Translational psychiatry · 2024Pooled it
- Genetic Basis of Tobacco Use Disorder.Genes · 2026Review
- Maternal Smoking During Pregnancy Interacts With Genetic Factors to Increase Risk for Low Birth Weight but Not Harmful Offspring Smoking Behaviors in Europeans.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2025Article
- Article
- Deep sequencing of candidate genes identified 14 variants associated with smoking abstinence in an ethnically diverse sample.Scientific reports · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Testing Association of Previously Implicated Gene Sets and Gene-Networks in Nicotine Exposed Mouse Models with Human Smoking Phenotypes.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Rare genetic variants explain missing heritability in smoking.Nature human behaviour · 2022Article
- Drinking and smoking polygenic risk is associated with childhood and early-adulthood psychiatric and behavioral traits independently of substance use and psychiatric genetic risk.Translational psychiatry · 2021Article
- Genome-wide methylation data improves dissection of the effect of smoking on body mass index.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
BACKGROUND AND
aimsAlthough genome-wide association studies have identified many loci that influence smoking behaviors, much of the genetic variance remains unexplained. We characterized the genetic architecture of four smoking behaviors using single nucleotide polymorphism (SNP) heritability (h
designPartitioned h
settingUK Biobank.
participantsUK Biobank participants of European ancestry. The number of participants varied depending on the trait, from 54 792 to 323 068. MEASUREMENTS: Smoking initiation, age of initiation, cigarettes per day (CPD; count, log-transformed, binned and dichotomized into heavy versus light) and smoking cessation with imputed genome-wide SNPs.
findingsWe estimated that, in aggregate, approximately 18% of the phenotypic variance in smoking initiation was captured by imputed SNPs [h
conclusionA biobank study of smoking behavior traits suggested that the phenotypic variance explained by SNPs of smoking initiation, age of initiation, cigarettes per day and smoking cessation is modest overall.
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