Evidence map›Paper›PMID 33620690›Full record

ArticleOphthalmology and therapy2021

Cross-Sectional Study on Vitamin D, Zinc Oxide and Fatty Acid Status in a Population with a Moderate to High Risk of AMD Identified by the STARS

Julie Jacob, Els Mangelschots, Marine Michez, Serdal N Sanak, Anita Leys

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Ophthalmology and therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04482465 (Omega 3 and Vitamin D Dosage in a Population With Moderate to High Risk of Age-related Macular Degeneration), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04482465 nacompletednot on this map

Omega 3 and Vitamin D Dosage in a Population With Moderate to High Risk of Age-related Macular Degeneration

TypeinterventionalSponsorUniversitaire Ziekenhuizen KU LeuvenRan2017 to 2017Enrolled50ConditionsAge-related Macular Degeneration, Vitamin D DeficiencyArmsblood sample
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Julie JacobDepartment of Ophthalmology, Universitair Ziekenhuis Leuven (UZ Leuven), Leuven, Belgium. Julie.jacob@uzleuven.be.
Els MangelschotsOogartsenpraktijk Alken, Alken, Belgium.
Marine MichezCliniques Universitaires Saint Luc, Université catholique de Louvain (UCLouvain), Brussels, Belgium.
Serdal N SanakDepartment of Ophthalmology, CHIREC-Hôpital Delta, Brussels, Belgium.
Anita LeysDepartment of Ophthalmology, Universitair Ziekenhuis Leuven (UZ Leuven), Leuven, Belgium.
Universitair Ziekenhuis Leuven · BECentre Hospitalier Interrégional Edith Cavell · BECliniques Universitaires Saint-Luc · BEZiekenhuis Oost-Limburg · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA prospective study was carried out in Belgium to determine the proportion of subjects with a moderate to high risk of developing age-related macular degeneration (AMD), identified using the STARS

methodsThis multicentre cross-sectional pilot study involved 50 Belgian subjects with no or early AMD, aged > 55 years who were at moderate to high risk for AMD. Subjects were assessed using the STARS

resultsAbnormal serum levels for at least one of the micronutrients was detected in 94% of the subjects. Lower than optimal vitamin D levels were found in 76% of the participants, and 68% of the subjects demonstrated at least one abnormal fatty acid profile. The Ω6:Ω3 ratio was above the reference range for normal values in 54% of the subjects; DHA and EPA levels were below the reference range in 60 and 46% of the subjects, respectively; and zinc oxide concentration was below the reference range in 50% of the subjects. Only 12% of the subjects exhibited cupric oxide deficiency.

conclusionIn this study, the STARS

trial registrationTrial registration: ClinicalTrials.Gov, identifier: NCT04482465.

Indexed as

AMDMicronutrientsOmega-6/omega-3Vitamin DZinc

Identifiers

PMID33620690
PMCPMC8079536
OpenAlexW3129878072

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.