Evidence map›Paper›PMID 33620673›Full record

ArticleCellular and molecular neurobiology2022

Association of MicroRNA Biogenesis Genes Polymorphisms with Risk of Large Artery Atherosclerosis Stroke.

Mengmeng Wang, Jinyu Gu, Chong Shen, Wuzhuang Tang, Xiaoru Xing, Zhizhong Zhang, Xinfeng Liu

Open access · greenAbstract read
In one paragraph

Article in Cellular and molecular neurobiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Frontiers in oncology · 2023
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Mengmeng Wang *Department of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China.ORCID http://orcid.org/0000-0002-9890-8900
Jinyu Gu *Department of Neurology, Jinling Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China.ORCID http://orcid.org/0000-0002-4528-3433
Chong ShenDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0001-6447-6591
Wuzhuang TangDepartment of Neurology, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China.ORCID http://orcid.org/0000-0001-5216-6596
Xiaoru XingDepartment of Neurology, Chinese PLA 983th Hospital, Tianjin, China.ORCID http://orcid.org/0000-0001-6204-1412
Zhizhong ZhangDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China. zhizhongn@163.com.ORCID http://orcid.org/0000-0002-2194-0857
Xinfeng LiuDepartment of Neurology, Jinling Hospital, Medical School of Nanjing University, 305 East Zhongshan Road, Nanjing, 210002, Jiangsu, China. xfliu2@ustc.edu.cn.ORCID http://orcid.org/0000-0002-8182-9632
Nanjing General Hospital of Nanjing Military Command · CNNanjing Medical University · CNJiangsu University · CN

Funding

National Natural Science Foundation of China 81530038National Natural Science Foundation of China 81771285
6 · The paper itself

Abstract

Convincing evidence has shown that microRNAs (miRNAs) are involved in the pathogenesis of stroke. This study aimed to examine whether miRNA biogenesis genes polymorphisms are associated with risk of large artery atherosclerosis (LAA) stroke. Three polymorphisms (DROSHA rs10719 T>C, RAN rs3803012 A>G, and PIWIL1 rs10773771 C>T) were screened by certain criteria. A total of 1,785 (710 cases and 1,075 controls) study subjects were included in this study. We found that rs10773771 CC genotype was associated with a decreased risk of LAA stroke (CC vs. TT/CT: OR 0.63, 95% CI 0.46-0.86, P = 3 × 10

Indexed as

Argonaute ProteinsAtherosclerosisMicroRNAsStroke3' Untranslated RegionsArteriesCase-Control StudiesGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single Nucleotide3' Untranslated RegionsArgonaute ProteinsMicroRNAsPIWIL1 protein, humanMicroRNA biogenesis genesPolymorphismStrokeSubtype

Identifiers

PMID33620673
PMCPMC11421748
OpenAlexW3133139612

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.