ArticleCurrent topics in microbiology and immunology2021
Natural Competence and Horizontal Gene Transfer in Campylobacter.
Article in Current topics in microbiology and immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 32 citations in OpenAlex.
- Cross-Host Adaptation ofMicroorganisms · 2026Article
- Identification of Outer Membrane Vesicles as a New Vehicle Mediating Antibiotic Resistance Gene Transfer in Campylobacter.Journal of extracellular vesicles · 2025Article
- Characterization of Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2025Article
- Genomic insights into the diversity, antimicrobial resistance and zoonotic potential ofMicrobial genomics · 2025Article
- Longitudinal and cross-sectional sampling and whole genome sequencing ofApplied and environmental microbiology · 2025Article
- Characterization of aquatic clade 2 and 3 Campylobacter coli isolates from Slovenia reveals admixture with other Campylobacter species.BMC microbiology · 2025Article
- Isolation and characterization of novel lytic bacteriophages against (fluoro)quinolone-resistantFrontiers in microbiology · 2025Article
- Therapeutic and protective approaches to combatFrontiers in pharmacology · 2025Review
- Campylobacter fetus isolates from both human patients and healthy cattle carry three distinct cytolethal distending toxin (cdt) gene clusters.The Journal of veterinary medical science · 2024Article
- Detection and characterization of Campylobacter in air samples from poultry houses using shot-gun metagenomics - a pilot study.BMC microbiology · 2024Article
- Graphite: painting genomes using a colored de Bruijn graph.NAR genomics and bioinformatics · 2024Article
- Genomic Analysis Points to Multiple Genetic Mechanisms for Non-TransformableMicroorganisms · 2024Article
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- Evaluation of core genome and whole genome multilocus sequence typing schemes forMicrobial genomics · 2023Article
- Cj0683 Is a Competence Protein Essential for Efficient Initialization of DNA Uptake inBiomolecules · 2023Article
- Overview of Virulence and Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2023Review
- Genomic Screening of Antimicrobial Resistance Markers in UK and USAntimicrobial agents and chemotherapy · 2022Article
- Antibiotic-resistantFrontiers in microbiology · 2022Article
- Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thermophilic Campylobacter, in particular Campylobacter jejuni, C. coli and C. lari are the main relevant Campylobacter species for human infections. Due to their high capacity of genetic exchange by horizontal gene transfer (HGT), rapid adaptation to changing environmental and host conditions contribute to successful spreading and persistence of these foodborne pathogens. However, extensive HGT can exert dangerous side effects for the bacterium, such as the incorporation of gene fragments leading to disturbed gene functions. Here we discuss mechanisms of HGT, notably natural transformation, conjugation and bacteriophage transduction and limiting regulatory strategies of gene transfer. In particular, we summarize the current knowledge on how the DNA macromolecule is exchanged between single cells. Mechanisms to stimulate and to limit HGT obviously coevolved and maintained an optimal balance. Chromosomal rearrangements and incorporation of harmful mutations are risk factors for survival and can result in drastic loss of fitness. In Campylobacter, the restricted recognition and preferential uptake of free DNA from relatives are mediated by a short methylated DNA pattern and not by a classical DNA uptake sequence as found in other bacteria. A class two CRISPR-Cas system is present but also other DNases and restriction-modification systems appear to be important for Campylobacter genome integrity. Several lytic and integrated bacteriophages have been identified, which contribute to genome diversity. Furthermore, we focus on the impact of gene transfer on the spread of antibiotic resistance genes (resistome) and persistence factors. We discuss remaining open questions in the HGT field, supposed to be answered in the future by current technologies like whole-genome sequencing and single-cell approaches.
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