Evidence map›Paper›PMID 33620598›Full record

ArticleDigestive diseases and sciences2022

Effects of Spinal Cord Stimulation in Patients with Chronic Nausea, Vomiting, and Refractory Abdominal Pain.

Leonardo Kapural, Bradbury Kenneth Brown, Shervin Harandi, Jared Rejeski, Kenneth Koch

Open access · hybridAbstract read
In one paragraph

Article in Digestive diseases and sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. 16. Pain in chronic pancreatitis.Pain practice : the official journal of World Institute of Pain · 2025
    Review
  2. Review
  3. Noninvasive electrical neuromodulation for gastrointestinal motility disorders.Expert review of gastroenterology & hepatology · 2023
    Review
  4. Article
  5. Neuromodulation for functional upper gastrointestinal diseases.Gut microbiota and integrative wellness · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Leonardo KapuralCarolinas Pain Institute, 145 Kimel Park Drive, Suite 330, Winston Salem, NC, 27103, USA. lkapuralmd@gmail.com.ORCID 0000-0003-2718-5837
Bradbury Kenneth BrownDepartment of Anesthesia, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Shervin HarandiModern Pain Management, Houston, TX, USA.
Jared RejeskiDepartment of Internal Medicine, Section on Gastroenterology, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Kenneth KochDepartment of Internal Medicine, Section on Gastroenterology, Wake Forest Baptist Medical Center, Winston Salem, NC, USA.
Atrium Health Wake Forest Baptist · USCarolinas Pain Institute · USPain Management Institute · USUniversity of North Carolina at Chapel Hill · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPatients with chronic nausea and vomiting often also have chronic abdominal pain. Spinal cord stimulation (SCS) may provide pain control, but scarce data are available regarding the effect of SCS on chronic nausea and vomiting.

aimsWe aimed to determine the effect of SCS in patients with chronic nausea, vomiting, and refractory abdominal pain.

methodsRetrospective chart review of 26 consecutive patients who underwent SCS trial for a primary diagnosis of nausea, vomiting and refractory abdominal pain.

results26 patients underwent SCS trial, with an average age of 48 years. Twenty-three patients (88.5%) reported > 50% pain relief during the temporary SCS trial and then underwent permanent implantation. Patients were then followed for 41 (22-62) months. At baseline, 20 of the 23 patients (87.0%) reported daily nausea, but at 6 months and the most recent follow-up, only 8 (34.8%) and 7 (30.4%) patients, respectively, had daily nausea (p < 0.001). Days of nausea decreased from 26.3 days/month at baseline to 12.8 and 11.7 days/month at 6 months and at the most recent visit, respectively. Vomiting episodes decreased by 50%. Abdominal pain scores improved from 8.7 to 3.0 and 3.2 at 6 months and the most recent visit, respectively (both p < 0.001). Opioid use decreased from 57.7 mg MSO4 equivalents to 24.3 mg at 6 months and to 28.0 mg at the latest patient visit (both p < 0.05).

conclusionsSCS may be an effective therapy for long-term treatment of symptoms for those patients afflicted with chronic nausea, vomiting, and refractory abdominal pain.

Indexed as

Abdominal PainAdultAgedAged, 80 and overChronic DiseaseChronic PainFemaleGastroparesisHumansMaleMiddle AgedNauseaSpinal Cord StimulationTreatment OutcomeVomitingChronic abdominal painChronic nausea and vomitingGastric dysmotilitySpinal cord stimulation

Identifiers

PMID33620598
PMCPMC8885488
OpenAlexW3131585553

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.