Trial reportEuropean journal of applied physiology2021
Effects of acute dietary nitrate supplementation on cold-induced vasodilation in healthy males.
Trial report in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Plasma nitrate, dietary nitrate, blood pressure, and vascular health biomarkers: a GRADE-Assessed systematic review and dose-response meta-analysis of randomized controlled trials.Nutrition journal · 2025Pooled it
- Nitrate ingestion blunts the increase in blood pressure during cool air exposure: a double-blind, placebo-controlled, randomized, crossover trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Trial
- Short-term cocoa bioflavanol supplementation does not improve cold-induced vasodilation in young healthy adults.European journal of applied physiology · 2024Trial
- Central versus peripheral mechanisms of cold-induced vasodilation: a study in the fingers and toes of people with paraplegia.European journal of applied physiology · 2023Trial
- Influence of acute beetroot juice supplementation on cold-induced vasodilation and fingertip rewarming.European journal of applied physiology · 2023Trial
- Cold-induced vasodilation: A meta-analysis.Temperature (Austin, Tex.) · 2026Review
- Recent updates on cold adaptation in population and laboratory studies, including cross-adaptation with nonthermal factors.Journal of physiological anthropology · 2025Review
- Exploring the role of nutritional strategies to influence physiological and cognitive mechanisms in cold weather operations in military personnel.Frontiers in physiology · 2025Review
- Finger anthropometrics may not be a primary influence on the thermal responses to cooling and rewarming.Temperature (Austin, Tex.) · 2023Article
- Acral skin vasoreactivity and thermosensitivity to hand cooling following 5 days of intermittent whole body cold exposure.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeCold-induced vasodilation (CIVD) is a paradoxical rise in blood flow to the digits that occur during prolonged cold exposure. CIVD is thought to occur through active vasodilation and/or sympathetic withdrawal, where nitric oxide (NO) may play a key role in mediating these mechanisms. Beetroot juice (BRJ) is high in dietary nitrate (NO
methodsParticipants had a resting blood pressure measurement taken prior to ingesting 140 mL of nitrate-rich BRJ (13 mmol NO
resultsCompared to PLA (100 ± 3 mmHg), acute BRJ supplementation significantly reduced mean arterial pressure at -30 min (96 ± 2 mmHg; p = 0.007) and 0 min (94 ± 2 mmHg; p = 0.008). Acute BRJ supplementation had no effect on Laser-Doppler fluxmetry during CIVD (expressed as cutaneous vascular conductance) measured as area under the curve (BRJ: 843 ± 148 PU mmHg
conclusionAcute BRJ supplementation does not augment the CIVD response in healthy males.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.