Evidence map›Paper›PMID 33620508›Full record

ReviewDer Anaesthesist2021

[Tranexamic acid for bleeding prophylaxis in orthopedic surgery and trauma-standard or customized therapy?]

Isabell Pekrul, Thomas Schachtner, Bernhard Zwißler, Patrick Möhnle

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Der Anaesthesist, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Isabell PekrulKlinik für Anaesthesiologie, Abteilung für Transfusionsmedizin, Zelltherapeutika und Hämostaseologie, Universität München (LMU), Marchioninistr. 15, 81377, München, Deutschland.
Thomas SchachtnerAnästhesie und Intensivmedizin, Schön Klinik München Harlaching, München, Deutschland.
Bernhard ZwißlerKlinik für Anaesthesiologie, Universität München (LMU), München, Deutschland.
Patrick MöhnleKlinik für Anaesthesiologie, Abteilung für Transfusionsmedizin, Zelltherapeutika und Hämostaseologie, Universität München (LMU), Marchioninistr. 15, 81377, München, Deutschland. patrick.moehnle@med.uni-muenchen.de.
Ludwig-Maximilians-Universität München · DELMU Klinikum · DESchön Klinik München Harlaching · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of tranexamic acid (TXA) is established in the treatment of bleeding, especially of bleeding due to hyperfibrinolysis. In recent years the prophylactic use of TXA in trauma and orthopedic surgery has increased leading to open questions regarding potentially associated risks and a possible classification as off label use. The available literature provides a sound basis for the recommendation that TXA can be used in these indications provided that an individual risk assessment is done in patients with increased risks for thromboembolic complications. Although the prophylactic use of TXA in orthopedic surgery and trauma is not explicitly listed in the product characteristics, it should not be regarded as an off label use.

Indexed as

Antifibrinolytic AgentsBlood Coagulation DisordersOrthopedic ProceduresTranexamic AcidBlood Loss, SurgicalHemorrhageHumansAntifibrinolytic AgentsTranexamic AcidAntifibrinolyticsAufklärungOff-label-usePerioperativeThromboembolic risk

Identifiers

PMID33620508
PMCPMC8190014
OpenAlexW3131094684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.