Evidence map›Paper›PMID 33620318›Full record

ArticleeLife2021

Exocyst-mediated membrane trafficking of the lissencephaly-associated ECM receptor dystroglycan is required for proper brain compartmentalization.

Andriy S Yatsenko, Mariya M Kucherenko, Yuanbin Xie, Henning Urlaub, Halyna R Shcherbata

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Andriy S Yatsenko *Institute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.
Mariya M Kucherenko *Max Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Yuanbin XieMax Planck Research Group of Gene Expression and Signaling, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Henning UrlaubBioanalytical Mass Spectrometry Research Group, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Halyna R ShcherbataInstitute of Cell Biochemistry, Hannover Medical School, Hannover, Germany.ORCID 0000-0002-3855-0345
Medizinische Hochschule Hannover · DEGannan Medical University · CNMax Planck Institute for Biophysical Chemistry · DEUniversitätsmedizin Göttingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To assemble a brain, differentiating neurons must make proper connections and establish specialized brain compartments. Abnormal levels of cell adhesion molecules disrupt these processes. Dystroglycan (Dg) is a major non-integrin cell adhesion receptor, deregulation of which is associated with dramatic neuroanatomical defects such as lissencephaly type II or cobblestone brain. The previously established

Indexed as

AnimalsDisease Models, AnimalDrosophila melanogasterDrosophila ProteinsDystroglycansLarvaLissencephalyNeuronsReceptors, Cell SurfaceDg protein, DrosophilaDrosophila ProteinsDystroglycansextracellular matrix receptorReceptors, Cell Surfacebrain neuropilscobblestone lissencephalydevelopmental biologydifferentiating neuronsD. melanogasterdystroglycanexocystneuronal Dg interactomeneuroscience

Identifiers

PMID33620318
PMCPMC7929561
OpenAlexW3129630817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.