ArticleJournal of natural products2021
Pharmacokinetics of Eleven Kratom Alkaloids Following an Oral Dose of Either Traditional or Commercial Kratom Products in Rats.
Open access · greenAbstract read
In one paragraph
Article in Journal of natural products, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 43 citations in OpenAlex.
- Simultaneous quantification of seventeen kratom alkaloids and metabolites in human plasma and its application to clinical pharmacokinetic sample analysis.Pharmaceutical biology · 2026Article
- A chromosome-level Mitragyna parvifolia genome unveils spirooxindole alkaloid diversification and mitraphylline biosynthesis.The Plant cell · 2025Article
- Alkaloid biosynthesis in medicinal crop kratom (Frontiers in plant science · 2025Article
- An In Vitro Examination of Whether Kratom Extracts Enhance the Cytotoxicity of Low-Dose Doxorubicin against A549 Human Lung Cancer Cells.Molecules (Basel, Switzerland) · 2024Article
- Pharmacokinetic Interaction of Kratom and Cannabidiol in Male Rats.Pharmaceutics · 2024Article
- Effects of kratom on driving: Results from a cross-sectional survey, ecological momentary assessment, and pilot simulated driving Study.Traffic injury prevention · 2024Article
- Growing pains with kratom: experiences discussed in subreddits contrast with satisfaction expressed in surveys.Frontiers in pharmacology · 2024Article
- Kratom's Emergence and Persistence Within the US Polydrug Epidemic.Current addiction reports · 2023Review
- Kratom alkaloid mitragynine: Inhibition of chemotherapy-induced peripheral neuropathy in mice is dependent on sex and active adrenergic and opioid receptors.IBRO neuroscience reports · 2022Article
- Respiratory effects of oral mitragynine and oxycodone in a rodent model.Psychopharmacology · 2022Article
- Social, psychological, and substance use characteristics of U.S. adults who use kratom: Initial findings from an online, crowdsourced study.Experimental and clinical psychopharmacology · 2022Article
- Kratom (Mitragyna speciosa) Validation: Quantitative Analysis of Indole and Oxindole Alkaloids Reveals Chemotypes of Plants and Products.Planta medica · 2022Article
- Metabolism of Speciociliatine, an Overlooked Kratom Alkaloid for its Potential Pharmacological Effects.The AAPS journal · 2022Article
- Clinical Pharmacokinetic Assessment of Kratom (Pharmaceutics · 2022Article
- Tissue Distribution, Excretion, and Interaction With Human Serum Albumin of Total Bioflavonoid Extract FromFrontiers in pharmacology · 2022Article
- Searching for a Signal: Self-Reported Kratom Dose-Effect Relationships Among a Sample of US Adults With Regular Kratom Use Histories.Frontiers in pharmacology · 2022Article
- Understanding Kratom Use: A Guide for Healthcare Providers.Frontiers in pharmacology · 2022Review
- Therapeutic benefit with caveats?: Analyzing social media data to understand the complexities of kratom use.Drug and alcohol dependence · 2021Article
- Evaluation of Kratom Opioid Derivatives as Potential Treatment Option for Alcohol Use Disorder.Frontiers in pharmacology · 2021Article
- Kratom Abuse Potential 2021: An Updated Eight Factor Analysis.Frontiers in pharmacology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Shyam H KambleDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-1664-1692
Erin C BertholdDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0003-2868-8073
Tamara I KingDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Siva Rama Raju KanumuriDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Raluca PopaDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Julius R HertingDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Francisco LeónDepartment of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0002-5064-2381
Abhisheak SharmaDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0003-0553-4039
Lance R McMahonDepartment of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Bonnie A AveryDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.
Christopher R McCurdyDepartment of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, Florida 32610, United States.ORCID 0000-0001-8695-2915
University of Florida · US
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MOpioid use disorders: UF Pharmacy medications discovery and developmentUG3DA048353 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2020
$3.6MKratom alkaloids: in vitro and in vivo pharmacological mechanismsR01DA047855 · NIDA · UNIVERSITY OF FLORIDA · PI MCCURDY, CHRISTOPHER R, MCMAHON, LANCE R. · 2019 to 2023
$3.6MNCATS NIH HHS UL1 TR001427NIDA NIH HHS R01 DA047855NIDA NIH HHS UG3 DA048353
Abstract
Kratom,
Indexed as
AlkaloidsAnimalsIndole AlkaloidsIndolesMaleMitragynaMolecular StructureOxindolesPlant PreparationsRatsRats, Sprague-DawleySecologanin Tryptamine AlkaloidsSpiro Compounds7-hydroxymitragynineAlkaloidscorynoxinecorynoxine BhirsutineIndole AlkaloidsIndolesmitragyninemitraphyllineOxindolespaynantheinePlant PreparationsraubasineSecologanin Tryptamine AlkaloidsspeciogynineSpiro Compounds
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.