ArticleMicrobial biotechnology2022
Alterations in the gut microbiome and metabolic profile in rats acclimated to high environmental temperature.
Article in Microbial biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Effect of New Zealand blackcurrant extract on rest and walking-induced cardiorespiratory and metabolic responses in young adult Southeast Asian women.European journal of applied physiology · 2026Article
- Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses.Microbiome · 2026Article
- Effects of anthocyanin-rich blackcurrant extract on cardiovascular and metabolic responses during rest and treadmill running: a case study in an elite national level female Southeast Asian endurance athlete.Frontiers in sports and active living · 2026Article
- Mechanisms underlying alterations of the gut microbiota by exercise and their role in shaping ecological resilience.FEMS microbiology reviews · 2025Review
- The mechanisms behind heatstroke-induced intestinal damage.Cell death discovery · 2024Review
- The Importance of Maintaining and Improving a Healthy Gut Microbiota in Athletes as a Preventive Strategy to Improve Heat Tolerance and Acclimatization.Microorganisms · 2024Review
- The gut microbiota facilitate their host tolerance to extreme temperatures.BMC microbiology · 2024Article
- Heat acclimation with probiotics-based ORS supplementation alleviates heat stroke-induced multiple organ dysfunction via improving intestinal thermotolerance and modulating gut microbiota in rats.Frontiers in microbiology · 2024Article
- Microbial communities are thermally more sensitive in warm-climate lizards compared with their cold-climate counterparts.Frontiers in microbiology · 2024Article
- Holistic view of heat acclimation alleviated intestinal lesion in mice with heat stroke based on microbiome-metabolomics analysis.Microbial biotechnology · 2023Article
- Effects of Microhabitat Temperature Variations on the Gut Microbiotas of Free-Living Hibernating Animals.Microbiology spectrum · 2023Article
- Alteration of gut microbiota after heat acclimation may reduce organ damage by regulating immune factors during heat stress.Frontiers in microbiology · 2023Article
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- Temperature Acclimation Alters the Thermal Tolerance and Intestinal Heat Stress Response in a Tibetan FishFrontiers in microbiology · 2022Article
- Gut Microbiota and Serum Metabolite Potential Interactions in Growing Layer Hens Exposed to High-Ambient Temperature.Frontiers in nutrition · 2022Article
- Cold Exposure during the Active Phase Affects the Short-Chain Fatty Acid Production of Mice in a Time-Specific Manner.Metabolites · 2021Article
- Potential Use of Gut Microbiota Composition as a Biomarker of Heat Stress in Monogastric Species: A Review.Animals : an open access journal from MDPI · 2021Review
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat acclimation (HA) is the best strategy to improve heat stress tolerance by inducing positive physiological adaptations. Evidence indicates that the gut microbiome plays a fundamental role in the development of HA, and modulation of gut microbiota can improve tolerance to heat exposure and decrease the risks of heat illness. In this study, for the first time, we applied 16S rRNA gene sequencing and untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics to explore variations in the gut microbiome and faecal metabolic profiles in rats after HA. The gut microbiota of HA subjects exhibited higher diversity and richer microbes. HA altered the gut microbiota composition with significant increases in the genera Lactobacillus (a major probiotic) and Oscillospira alongside significant decreases in the genera Blautia and Allobaculum. The faecal metabolome was also significantly changed after HA, and among the 13 perturbed metabolites, (S)-AL 8810 and celastrol were increased. Moreover, the two increased genera were positively correlated with the two upregulated metabolites and negatively correlated with the other 11 downregulated metabolites, while the correlations between the two decreased genera and the upregulated/downregulated metabolites were completely contrary. In summary, both the structure of the gut microbiome community and the faecal metabolome were improved after 28 days of HA. These findings provide novel insights regarding the improvement of the gut microbiome and its functions as a potential mechanism by which HA confers protection against heat stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.