Evidence map›Paper›PMID 33620141›Full record

ArticleThe journal of pathology. Clinical research2021

Variability in grading of ductal carcinoma in situ among an international group of pathologists.

Maartje van Seijen, Katarzyna Jóźwiak, Sarah E Pinder, Allison Hall, Savitri Krishnamurthy, Jeremy Sj Thomas, Laura C Collins, Jonathan Bijron, Joost Bart, Danielle Cohen and 9 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in The journal of pathology. Clinical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

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  20. Should low-risk DCIS lose the cancer label? An evidence review.Breast cancer research and treatment · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 13 institutions in 4 countries.

Maartje van SeijenDivision of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-9348-239X
Katarzyna JóźwiakDivision of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Sarah E PinderComprehensive Cancer Centre at Guy's Hospital, School of Cancer & Pharmaceutical Sciences, Kings College London, London, UK.
Allison HallDepartment of Pathology, Duke University Medical Center, Durham, NC, USA.
Savitri KrishnamurthyDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jeremy Sj ThomasDepartment of Pathology, Western General Hospital, Edinburgh, UK.
Laura C CollinsDepartment of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Jonathan BijronDepartment of Pathology, Martini Hospital, Groningen, The Netherlands.
Joost BartDepartment of Pathology, Isala Hospital, Zwolle, The Netherlands.
Danielle CohenDepartment of Pathology, Leiden University Medical Center, Leiden, The Netherlands.
Wen NgDepartment of Cellular Pathology, Guy's and St Thomas' NHS Foundation Trust London, London, UK.
Ihssane BouybayouneComprehensive Cancer Centre at Guy's Hospital, School of Cancer & Pharmaceutical Sciences, Kings College London, London, UK.
Hilary StobartIndependent Cancer Patients' Voice, London, UK.
Jan HudecekDepartment of Research IT, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Michael SchaapveldDepartment of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Alastair ThompsonDan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX, USA.
Esther H Lips *Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Jelle Wesseling *Division of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.ORCID 0000-0002-8940-2676
Grand Challenge PRECISION consortium.
The Netherlands Cancer Institute · NLGuy's Hospital · GBBaylor College of Medicine · USBeth Israel Deaconess Medical Center · USDuke Medical Center · USDutch Cancer Society · NLGuy's and St Thomas' NHS Foundation Trust · GBLeiden University Medical Center · NLMartini Ziekenhuis · NLThe Patients Association · GBThe University of Texas MD Anderson Cancer Center · USUniversity Medical Center Groningen · NLWestern General Hospital · GB

Funding

Cancer Research UK C38317/A24043
6 · The paper itself

Abstract

The prognostic value of cytonuclear grade in ductal carcinoma in situ (DCIS) is debated, partly due to high interobserver variability and the use of multiple guidelines. The aim of this study was to evaluate interobserver agreement in grading DCIS between Dutch, British, and American pathologists. Haematoxylin and eosin-stained slides of 425 women with primary DCIS were independently reviewed by nine breast pathologists based in the Netherlands, the UK, and the USA. Chance-corrected kappa (κ

Indexed as

PathologistsBiomarkers, TumorBiopsyBreast NeoplasmsCarcinoma, Intraductal, NoninfiltratingErb-b2 Receptor Tyrosine KinasesEuropeFemaleHumansImmunohistochemistryNeoplasm GradingObserver VariationPredictive Value of TestsReceptors, EstrogenReproducibility of ResultsRetrospective StudiesBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesReceptors, Estrogenductal carcinoma in situgradeinterobserver variabilitypathology

Identifiers

PMID33620141
PMCPMC8073001
OpenAlexW3130361190

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.