Evidence map›Paper›PMID 33620125›Full record

ArticleHead & neck2021

The prognostic significance of race in nasopharyngeal carcinoma by histological subtype.

Katelyn O Stepan, Angela L Mazul, S Andrew Skillington, Randal C Paniello, Jason T Rich, Jose P Zevallos, Ryan S Jackson, Patrik Pipkorn, Sean Massa, Sidharth V Puram

Open access · greenAbstract read
In one paragraph

Article in Head & neck, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Machine learning prognostication in nasopharyngeal carcinoma: a european multicentre analysis of survival and risk of second malignancy.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  2. Article
  3. Health Disparities in Rhinology-A Scoping Review.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025
    Article
  4. Review
  5. Nasopharyngeal carcinoma. A "different" head and neck tumour. Part B: treatment, prognostic factors, and outcomes.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Review
  6. Nasopharyngeal carcinoma. A "different" head and neck tumour. Part A: from histology to staging.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Katelyn O StepanDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.
Angela L MazulDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.
S Andrew SkillingtonDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0002-9811-9223
Randal C PanielloDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.
Jason T RichDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.
Jose P ZevallosDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0002-9111-6767
Ryan S JacksonDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0003-4626-2324
Patrik PipkornDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.
Sean MassaDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0003-2015-9855
Sidharth V PuramDepartment of Otolaryngology, Washington University School of Medicine, St Louis, Missouri, USA.ORCID 0000-0003-3543-889X
Washington University in St. Louis · US

Funding

Integrating social and molecular determinants of HPV-associated cancersK01MD013897 · NIMHD · WASHINGTON UNIVERSITY · PI MAZUL, ANGELA LIU · 2020 to 2023
$519k
National Institute of Minority Health and Health Disparities K01MD013897NIMHD NIH HHS K01 MD013897
6 · The paper itself

Abstract

backgroundRace has been shown to have variable prognostic importance in nasopharyngeal carcinoma (NPC). However, previous studies are limited by a lack of comprehensive treatment, epidemiologic, and comorbidity data.

methodsThis was a retrospective cohort study utilizing the National Cancer Database from 2004 to 2016. Multivariable Cox proportional hazards regressions were used to calculate adjusted hazard ratios (aHR) for overall survival.

resultsA cohort of 9995 patients met inclusion and exclusion criteria. Race, insurance, comorbidity, treatment, stage, age, and histology were independent prognosticators. Among patients with keratinizing NPC, Asians and Hispanics had superior survival (aHR 0.58 [95% confidence interval (CI) 0.48-0.69], aHR 0.76 [95% CI 0.61-0.96]) compared to white patients. Among patients with non-keratinizing differentiated NPC, Asians and black patients had improved survival (aHR 0.71 [95% CI 0.56-0.91], aHR 0.72 [95% CI 0.54-0.95]) compared to white patients. Race was not prognostic in non-keratinizing undifferentiated NPC.

conclusionThe prognostic significance of race varies across histological subtypes of NPC.

Indexed as

Head and Neck NeoplasmsNasopharyngeal NeoplasmsHumansNasopharyngeal CarcinomaPrognosisRetrospective Studiesnasopharyngeal carcinomaprognosisracesurvival

Identifiers

PMID33620125
PMCPMC8480514
OpenAlexW3131370791

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.