Evidence map›Paper›PMID 33620010›Full record

ArticleDrug delivery2021

Transdermal iontophoresis delivery system for terazosin hydrochloride: an

Changzhao Jiang, Xiumei Jiang, Xiumin Wang, Jiaxu Shen, Mengjie Zhang, Leilei Jiang, Rui Ma, Tingting Gan, Yingbiao Gong, Jincui Ye and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Changzhao JiangKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Xiumei JiangKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Xiumin WangKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Jiaxu ShenCollaborative Innovation Center of Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Mengjie ZhangKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Leilei JiangKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Rui MaKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Tingting GanCollaborative Innovation Center of Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Yingbiao GongCollaborative Innovation Center of Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Jincui YeKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Wenyan GaoKey Laboratory of Neuropsychiatric Drug Research of Zhejiang Province, Institute of Materia Medica, Hangzhou Medical College, Hangzhou, China.
Hangzhou Medical College · CNZhejiang University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to construct a transdermal iontophoresis delivery system for terazosin hydrochloride (IDDS-TEH), which included a positive and negative electrode hydrogel prescription. Intact guinea pig skin was used as a model for the skin barrier function, and the current intensity, terazosin hydrochloride (TEH) concentration, pH, competitive salt, and transdermal enhancer properties were studied. The blood drug concentration was determined in Sprague-Dawley (SD) rats using HPLC, and the antihypertensive effects of IDDS-TEH were evaluated in spontaneously hypertensive rats (SHRs). The results showed that the steady-state penetration rate of TEH increased (from 80.36 µg·cm

Indexed as

Drug Delivery SystemsAdministration, CutaneousAdrenergic alpha-1 Receptor AntagonistsAnimalsAntihypertensive AgentsArea Under CurveBlood PressureChromatography, High Pressure LiquidFemaleGuinea PigsHypertensionIontophoresisMalePrazosinRatsRats, Inbred SHRAdrenergic alpha-1 Receptor AntagonistsAntihypertensive AgentsPrazosinTerazosinblood pressureiontophoresispharmacokineticsTerazosin hydrochloridetransdermal drug delivery

Identifiers

PMID33620010
PMCPMC7906618
OpenAlexW3132260058

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.