ArticleJournal of cachexia, sarcopenia and muscle2021
Incidence of cardiovascular disease and mortality in underweight individuals.
Article in Journal of cachexia, sarcopenia and muscle, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
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Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Relationship Between Body Mass Index and Recurrence Risk of Stroke: A Systematic Review and Dose-Response Meta‑Analysis.Brain and behavior · 2025Pooled it
- The relationship between body mass index and stroke: a systemic review and meta-analysis.Journal of neurology · 2022Pooled it
- Low body mass index is not necessarily low cardiovascular risk in hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Associations of body mass index and metabolic health with stroke risk in a large prospective cohort with time updated covariates.Scientific reports · 2026Article
- "Health literacy, health behavior, and demographic determinants of BMI status among pre-older adults: a cross-sectional study".BMC nutrition · 2026Article
- Impact of body mass index on hospital mortality of old and oldest- old critically ill patients: a retrospective study.BMC geriatrics · 2026Article
- The impact of body mass index on health service utilization among pilgrims: a comprehensive analysis.Frontiers in epidemiology · 2026Article
- Insights Into Stroke Risk and Prediction for Underweight Individuals.Neurosciences (Riyadh, Saudi Arabia) · 2026Review
- Development and validation of an interpretable machine learning model for pulmonary heart disease in patients with pneumoconiosis.Frontiers in public health · 2026Article
- Association of organ dysfunction trajectories and major adverse cardiovascular events using clinical obesity in UK Biobank.Frontiers in endocrinology · 2026Article
- The positive correlation between the triglyceride glucose-body mass index and the presence and severity of early-onset coronary artery disease.Annals of medicine · 2025Article
- 2024 Obesity Fact Sheet in Korea: Prevalence of Obesity, Abdominal Obesity, Obesity Defined by Body Fat Percentage, and Underweight in Adults in Korea from 2013 to 2022.Journal of obesity & metabolic syndrome · 2025Article
- Joint effects of triglyceride glucose index and its obesity-related derivatives with estimated glucose disposal rate on cardiometabolic multimorbidity in middle-aged and older Chinese adults: a nationwide cohort study.Cardiovascular diabetology · 2025Article
- Article
- AHA's Life's Essential-8 cardiovascular health metrics and progression of coronary artery calcification in Japanese men.American journal of preventive cardiology · 2025Article
- Shape of You: Eye-Tracking and Social Perceptions of the Human Body.Behavioral sciences (Basel, Switzerland) · 2025Article
- The Influence of the Sympathetic Nervous System on Cardiometabolic Health in Response to Weight Gain or Weight Loss.Metabolites · 2025Review
- Article
- Miodynamic and Radiographic Evaluation in Recreative Athletes with Patellofemoral Pain.Medicina (Kaunas, Lithuania) · 2024Article
- Association between physical activity levels and mortality across adiposity: A longitudinal study of age-specific Asian populations.Geriatrics & gerontology international · 2024Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have evaluated the association between being underweight and having cardiovascular disease in the general population. We investigated the incidence of stroke, myocardial infarction (MI), and all-cause mortality according to detailed underweight categories in a large population cohort.
methodsWe included 4 164 364 individuals who underwent a health examination that was conducted as part of the Korean National Health Insurance Service between January 2009 and December 2012 and followed them up to determine the incidence of stroke, MI, and all-cause mortality until 31 December 2016. Based on the body mass index, the study population was categorized into normal (18.50-22.99), mild (17.00-18.49), moderate (16.00-16.99), and severe underweight (<16.00) groups. Cox proportional hazards analyses were performed to calculate the hazard ratio for stroke, MI, and mortality according to the severity of underweight in reference to the normal weight. We adjusted for age, sex, lifestyle, economic status, co-morbidity, blood pressure, glucose, lipid level, and waist circumference.
resultsThe mean age of the 4 164 364 eligible subjects in this study cohort was 44.4 ± 14.3 years, and 46.1% of the participants were male; 46 728 strokes, 30 074 MIs, and 121 080 deaths occurred during 27 449 902 person-years. The incidence of stroke, MI, and all-cause mortality increased proportionally with the severity of underweight in the multivariate model. This proportional association became more evident when the waist circumference was additionally adjusted. The respective hazard ratios (95% confidence intervals) for mild, moderate, and severe underweight were 1.10 (1.06-1.15), 1.11 (1.02-1.20), and 1.38 (1.24-1.53) for stroke; 1.19 (1.14-1.25), 1.40 (1.27-1.53), and 1.86 (1.64-2.11) for MI; and 1.63 (1.60-1.67), 2.10 (2.02-2.17), and 2.98 (2.85-3.11) for all-cause mortality. In stratified analyses based on waist circumference, the severity of underweight was consistently associated with a higher risk of stroke, MI, and death.
conclusionsThe severity of underweight was associated with a higher risk of stroke, MI, and all-cause mortality.
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